The data below illustrates the role of MutS, MutH and Dam in DNA repair. Strains of E coli that are wild-type (FX-11) or with inactive forms of MutS or MutH as well as strains without dam methylase. Explain the function of MutS and MutH and why their deletion enhance the mutation rate of E coli. Why does deletion of the dam gene increase the mutation rate further?
Bacterial Genomics
The study of the morphological, physiological, and evolutionary aspects of the bacterial genome is referred to as bacterial genomics. This subdisciplinary field aids in understanding how genes are assembled into genomes. Further, bacterial or microbial genomics has helped researchers in understanding the pathogenicity of bacteria and other microbes.
Transformation Experiment in Bacteria
In the discovery of genetic material, the experiment conducted by Frederick Griffith on Streptococcus pneumonia proved to be a stepping stone.
Plasmids and Vectors
The DNA molecule that exists in a circular shape and is smaller in size which is capable of its replication is called Plasmids. In other words, it is called extra-chromosomal plasmid DNA. Vectors are the molecule which is capable of carrying genetic material which can be transferred into another cell and further carry out replication and expression. Plasmids can act as vectors.
The data below illustrates the role of MutS, MutH and Dam in DNA repair. Strains of E coli that are wild-type (FX-11) or with inactive forms of MutS or MutH as well as strains without dam methylase. Explain the function of MutS and MutH and why their deletion enhance the mutation rate of E coli. Why does deletion of the dam gene increase the mutation rate further?
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