The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane? Objective: Perform calculations about the free energy change and electric potentialacross various membranes, illustrating differences between them.1. Recall the membrane proton-transport free energy equation:AG = 2.3 RT [pH(side 1) - pH (side 2)] + Z FAY=where Z = the charge on the proton (+1), F = Faraday's constant = 96485 C/mol and Rgas constant = 8.314 J/K mol.For the inner membrane of a mitochondrion, AY = + 0.168 V; use T = 310K (37°C) andpH(matrix) - pH (intermembrane space) = 0.75.

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The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?

The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?

Biochemistry

9th Edition

ISBN:9781305961135

Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal

Publisher:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal

Chapter8: Lipids And Proteins Are Associated In Biological Membranes

Section: Chapter Questions

Problem 39RE: REFLECT AND APPLY Which statements are consistent with the known facts about membrane transport? (a)...

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