The following diagram is from a paper investigating the role of B4 integrin in breast cancer. They exarmined t Increasing relative C expression B4- B4+ MIRNA

Biology Today and Tomorrow without Physiology (MindTap Course List)
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Author:Cecie Starr, Christine Evers, Lisa Starr
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Chapter7: Gene Expression And Control
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The following diagram is from a paper investigating the role of β4 integrin in breast cancer.  They examined the expression of miRNAs (rows) in ten β4 positive and ten β4 negative breast cancers.  Each array was performed in triplicate (columns) (Gerson, 2012).

A.    Describe how you think this array was carried out. 

 B.     β4 integrin is normally involved in attaching epithelial cells to the extracellular matrix and holding them in place, but in cancer, it can be involved in attaching cells to actin and increasing motility as well as in cell signaling.  How is β-integrin expression related to miRNA expression?  What do you think this means for these breast cancers?

The following diagram is from a paper investigating the role of B4 integrin in breast cancer. They exarmined t
Increasing
relative
C
expression
B4-
B4+
MIRNA
Transcribed Image Text:The following diagram is from a paper investigating the role of B4 integrin in breast cancer. They exarmined t Increasing relative C expression B4- B4+ MIRNA
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