The Mechanism of Action of Cyclophosphamide and its toxicity
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The Mechanism of Action of Cyclophosphamide and its toxicity
reference :http://dx.doi.org/10.3390/scipharm88040042 (reseach paper DOI plz answer in detail do not give short answer )
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- Present the rationale for clinical applications of niacin. What are major side effects?In 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.What is infusion related toxicity and slower toxicity of amphotericin B? How can these be minimized?
- what possible outcome may be produced when the molecular weight of an alcohol antiseptic is increase to a C20, will it still be effective? Explain your answerWhat are the measures to inhibit the Maillard reaction in undesirable situations. please explain detailedIndicate which reactions of purine or pyrimidine metabolism are affected by the inhibitors (a) azaserine, (b) methotrexate, (c) sulfonamides, (d) allopurinol, and (e) 5-fluorouracil.
- In 2-page worth of words (around 500), discuss in depth the risks and hazards of CYCLAMATE in the body. What will be the reactions and the harmful products and their effects? Why is this a concern?Discuss the biochemical effects of acute vs. chronic ethanol intoxication and show the significant differences between these two states on patient management. Explain how consumption of ethanol can lead to hyperuricaemia and gout in high-risk patientsElevated blood plasma levels of alkaline phosphatase (hyperphosphatasaemia) are an indication of a number of pathologies. Briefly comment on the use of alkaline phosphatase assays as a diagnostic aid for a single common medical condition. (word limit 120 words including citations and references.
- When can the H-H equation be used clinically/Explain the role of L-tartrate in the determination of acid phosphatase . Differentiate thymolphthalein monophosphate method from alpha naphthyl phosphate method of prostatic acid phosphate determination. Why is acid phosphatase determination useful in establishing recent sexual intrusion as in the case of alleged rape? EXPLAIN 3-5 SENTENCESOne treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia.
