The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma wereobtained experimentally at various temperatures (T) and pH values. The results are presented in thefollowing table:pH=7.00.720.84pH=6.25pH=7.25T= 27 C0.240.89T= 30 C0.311.06T= 40 C1.231.4927.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and thenpartitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in waterafter in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place)Answer: 19.01

The partition coefficients for a drug at various pH and water are given. We are required to find out…

The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma were obtained experimentally at various temperatures (T) and pH values. The results are presented in the following table: pH=6.25 pH=7.0 pH=7.25 T= 27 C 0.24 0.72 0.89 T= 30 C 0.31 0.84 1.06 T= 40 C 1.23 27.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and then partitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in water after in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place) 1.49 Answer: 19.01

The octanol - water aqueous buffer partition coefficients (P) for a drug used to treat glaucoma were obtained experimentally at various temperatures (T) and pH values. The results are presented in the following table: pH=6.25 pH=7.0 pH=7.25 T= 27 C 0.24 0.72 0.89 T= 30 C 0.31 0.84 1.06 T= 40 C 1.23 27.4 mg of this drug were dissolved in 100 mL of buffered water (pH=7.0; T=30) and then partitioned with octanol portions of 37.1 mL. Calculate how many mg of drug will remain in water after in the first extraction (Fill in ONLY numbers approximated to the 2nd decimal place) 1.49 Answer: 19.01

Appl Of Ms Excel In Analytical Chemistry

2nd Edition

ISBN:9781285686691

Author:Crouch

Publisher:Crouch

Chapter14: Chromatography

Section: Chapter Questions

Problem 10P

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