The synthesis of suprofen, a potent non-steroidal anti-inflammatory drug, from thiophene is proposed following the sequence of reactions shown below. H3C. `N' CHз (DMF) РОСЗ steps `s Na,CO3, H20 CI H thiophene Q AICI3 CH3 2-(1-phenylethyl)- 1,3-dioxolane P.

The synthesis of suprofen, a potent non-steroidal anti-inflammatory drug, from thiophene is proposed following the sequence of reactions shown below. H3C. `N' CHз (DMF) РОСЗ steps `s Na,CO3, H20 CI H thiophene Q AICI3 CH3 2-(1-phenylethyl)- 1,3-dioxolane P.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter22: Reactions Of Benzene And Its Derivatives

Section: Chapter Questions

Problem 22.28P

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Concept explainers

Sulfur Functional Groups

Many organic molecules contain sulfur functional groups and have their own importance in chemistry as well as biology. Some of the organic molecules which contain sulfur functional groups and the corresponding sulfur functionality is given below:

Question

Provide the mechanism for the Friedel-Crafts acylation reaction of compound Q and 2-(1- phenylethyl)-1,3-dioxolane that leads to the formation of intermediate R.

The synthesis of suprofen, a potent non-steroidal anti-inflammatory drug, from thiophene is proposed
following the sequence of reactions shown below.
H3C
H.
CHз (DMF)
POCI3
steps
Na,CO3, H20
H
CI
thiophene
AICI3
CH3
2-(1-phenylethyl)-
1,3-dioxolane
steps
HO2C
S.
CH3
CH3
R
suprofen

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