The typical distribution of K+ and Na+ ions inside and outside the cell is: [K+]in = 150 mM; [K+]out = 5 mM; [Na+]in = 10 mM; [Na+]out = 150 mM What should be the ratios of PNa/PK at (i) rest (-60 mV) and (ii) during the action potential (+20 mV) to generate a spike from -60 to +20 mV. Use the short form of Goldman equation.

Principles of Instrumental Analysis
7th Edition
ISBN:9781305577213
Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
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Chapter23: Potentiometry
Section: Chapter Questions
Problem 23.7QAP
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The typical distribution of K+ and Na+ ions inside and outside the cell is:

[K+]in = 150 mM; [K+]out = 5 mM;

[Na+]in = 10 mM; [Na+]out = 150 mM

What should be the ratios of PNa/PK at (i) rest (-60 mV) and (ii) during the action potential (+20 mV) to generate a spike from -60 to +20 mV. Use the short form of Goldman equation.

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