This is a graph of the expected frequency of a deleterious allele, with a constant mutation rate, within a population at different levels of selection against it. 0.00012 0.00001 0.000008 0.000006 0.000004 0.000002 0.2 0.4 0.6 0.8 H= 10 i) What is the overall trend shown? i) What is the mutation-selection balance? ii) The formula for the equilibrium frequency of a deleterious allele within a population is p^=u/swhere u is the mutation rate and s is the selection coefficient. Using the relationships illustrated by this formula, determine the following for a population with two deleterious alleles A and B: a) If A has a high mutation rate and low selection coefficient, and B has a low mutation rate and a medium selection coefficient, which would deleterious allele would be expected to be seen in higher frequency? vd

This is a graph of the expected frequency of a deleterious allele, with a constant mutation rate, within a population at different levels of selection against it. 0.00012 0.00001 0.000008 0.000006 0.000004 0.000002 0.2 0.4 0.6 0.8 H= 10 i) What is the overall trend shown? i) What is the mutation-selection balance? ii) The formula for the equilibrium frequency of a deleterious allele within a population is p^=u/swhere u is the mutation rate and s is the selection coefficient. Using the relationships illustrated by this formula, determine the following for a population with two deleterious alleles A and B: a) If A has a high mutation rate and low selection coefficient, and B has a low mutation rate and a medium selection coefficient, which would deleterious allele would be expected to be seen in higher frequency? vd

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 23QP

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