Transcribe and translate the mutated sequence #2. Determine the consequence, if any, for each mutation. You will need to use your codon charts in you ISN. Practice with both charts. Original DNA sequence: mRNA transcript: amino acids: Mutated DNA sequence #2: mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) How did the mutation affect the amino acid sequence (protein)? (Circle all that apply.) ARG Point TAC AUG METH TAC Silent (No change) ACC UGG TRP GAC Substitution Missense (1 amino acid changed) TTG AAC CUG :: PRO :: AUG :: ASN ASN CTT Nonsense (Premature stop) signal GCG CGC ARG GGC Frameshift No stop signal ACG UGC CYS GAC ACT CCG :: GAA :: GLU UGA STOP GAC T Insertion or 1 amino acid added/ deleted LEU Deletion All the amino acids changed after the point of mutation :: Stop ::Start

Human Anatomy & Physiology (11th Edition)
11th Edition
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Chapter1: The Human Body: An Orientation
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Transcribe and translate the mutated sequence # 2. Determine the consequence, if any, for each mutation. You wi ISN. Practice with both charts. Original DNA sequence: mRNA transcript: amino acids: Mutated DNA sequence #2: mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) How did the mutation affect the amino acid sequence (protein)? (Circle all that apply.) #ARG Point TAC AUG METH TAC Silent (No change) || || CUG #PRO ACC UGG TRP GAC Substitution Missense (1 amino acid changed) #AUG TTG AAC ASN ASN CTT Nonsense (Premature stop) signal GCG CGC ARG GGC Frameshift No stop signal ACG UGC CYS GAC GAC # CCG #GAA #GLU Inserti 1 amino ac added/ deleted LE

Transcribe and translate the mutated sequence #2. Determine the consequence, if any, for each mutation. You will need to use your codon charts in your
ISN. Practice with both charts.
Original DNA
sequence:
mRNA transcript:
amino acids:
Mutated DNA
sequence #2:
mRNA transcript:
(Circle any changes)
amino acids:
Type of
mutation
(Circle one.)
How did the
mutation affect
the amino acid
sequence
(protein)?
(Circle all that
apply.)
Point
TAC
AUG
METH
TAC
Silent
(No
change)
ACC
UGG
TRP
GAC
Substitution
Missense
(1 amino
acid
changed)
TTG
AAC
ASN
CTT
Nonsense
(Premature
stop)
signal
:: ARG # CUG :: PRO :: AUG :: ASN
GCG
CGC
ARG
GGC
Frameshift
No stop
signal
CCG :: GAA
ACG
UGC
CYS
GAC
ACT
:: GLU
UGA
STOP
GAC T
Insertion or
1 amino acid
added/
deleted
Deletion
All the amino acids
changed after the
point of mutation
LEU :: Stop :: Start
Transcribed Image Text:Transcribe and translate the mutated sequence #2. Determine the consequence, if any, for each mutation. You will need to use your codon charts in your ISN. Practice with both charts. Original DNA sequence: mRNA transcript: amino acids: Mutated DNA sequence #2: mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) How did the mutation affect the amino acid sequence (protein)? (Circle all that apply.) Point TAC AUG METH TAC Silent (No change) ACC UGG TRP GAC Substitution Missense (1 amino acid changed) TTG AAC ASN CTT Nonsense (Premature stop) signal :: ARG # CUG :: PRO :: AUG :: ASN GCG CGC ARG GGC Frameshift No stop signal CCG :: GAA ACG UGC CYS GAC ACT :: GLU UGA STOP GAC T Insertion or 1 amino acid added/ deleted Deletion All the amino acids changed after the point of mutation LEU :: Stop :: Start
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