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- A common membrane-bound intermediary between the receptor and the effector protein within the plasma membrane is the __________________.Explain whether the specificity of interaction will be high or low for each given situation. a. The value of KD of the ligand's interaction to the target receptor is very much lower than the value of KD of the ligand's interaction to off-targets. b. The ligand concentration [L] is higher than the KD value of its interaction with the target and the KD value of its interaction to off-targets.Explain whether the specificity of interaction will be high or low for each given situation. a. The concentration of the ligand's complex to the target receptor equates to the concentration of the ligand's complex to off-targets. b. The target receptor's total concentration is very much higher than the off-target's total concentration.
- What will be the receptor probability of the active state after you add a high dose of an antagonist?You can choose one or more than one option The dissociation constant (Kd) of a receptor is: the concentration of a ligand that produces 100% occupancy of the receptor the concentration of a ligand that produces 50% of the maximal effect. the measurement of specificity between ligand and its receptor. the measurement of speed by which a ligand will dissociate from its receptor. the measurement of affinity between a ligand and its receptor and the inverse of the association constant.Choose the best term which describe the following statement: antagonist binds to the binding site of receptor and change the shape: Select one: Incorrect Induced fit. Correct induced fit. Signal transduction. Perfect fit.
- A specific stimulus produces a receptor potential by :-a- inhibiting Na + influx into receptorb- inhibiting K + efflux from receptorc- enhancing Na + influx into receptord- enhancing K + efflux from receptorMaximal physiological response to an external stimuli typically occurs when ______ of the receptors are bound by its ligand. A. None of the answers are true. B. All of the answers are true. C. Only a fraction D. 100% E. Most F. at least 50% G. Ligand-bound receptors do not result in any detectable physiological responses.A ligand binds two different receptors with a Kd value of 10−7 M for receptor 1 and a Kd value of 10−9 M for receptor 2. For which receptor does the ligand show the greater affinity? Calculate the fraction of receptors that have a bound ligand ([RL]/RT) in the case of receptor 1 and receptor 2 if the con- centration of free ligand is 10−8 M.
- When activating what kind of receptor do you get the fastest (physiological) response? Select an option: a.Transport protein-coupled receptors b.G-protein-coupled receptorsIntracellular receptors c.Ion channel coupled receptorsTyrosine kinase-coupled receptorsBriefly explain the difference between a receptor antagonist and a receptor inverse agonist. Describe both the resulting receptor conformation as well as the signal transduction.Estimate the binding affi nity of a ligand for its receptor from the followingdata: