Using a pH meter, verify that 100 mL of distilled water is neutral. Dissolve 50.0 mg of naproxen drug substance, accurately weighed, in 50 mL of methanol. Add 25 mL of the neutralized water and mix. Add two drops of phenolphthalein as the indicator. What is the blank sample in this experiment? How many sample and blank titrations are required for this experiment? Use the equation below to calculate your expected end-point volume. Each mL of 0.01 N sodium hydroxide is equivalent to 2.303 mg of naproxen, C14H14O3

Chemistry: Matter and Change
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Chapter18: Acids And Bases
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Using a pH meter, verify that 100 mL of distilled water is neutral.
Dissolve 50.0 mg of naproxen drug substance, accurately weighed, in 50 mL of methanol. Add 25 mL of the neutralized water and mix. Add two drops of
phenolphthalein as the indicator.

  1. What is the blank sample in this experiment?
  2. How many sample and blank titrations are required for this experiment?
  3. Use the equation below to calculate your expected end-point volume.

Each mL of 0.01 N sodium hydroxide is equivalent to 2.303 mg of naproxen,
C14H14O3

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