Using a Stork enamine synthesis, show how you might accomplish the following transformation: مهدديد The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. R R A. & 8 d B. MgBr D.H3O* E. 1) NaH; 2) Mel F. R₂NH, [H] (-H₂O)

Using a Stork enamine synthesis, show how you might accomplish the following transformation: مهدديد The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. R R A. & 8 d B. MgBr D.H3O* E. 1) NaH; 2) Mel F. R₂NH, [H] (-H₂O)

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter19: Enolate Anions And Enamines

Section: Chapter Questions

Problem 19.57P

See similar textbooks

Similar questions

Methamphetamine is a long-lasting, potent stimulant sold as a street drug. The synthesis is quite simple and one step in the synthesis is shown below. Using your knowledge of the reactions of amines, provide all the reagents necessary to complete the reaction below. Provide the reagents for step 1 and step 2 ,
For the following reaction schemes, fill in the appropriate reagents and starting materials you would use to transform the acetoacetic ester and acetone into nabumetone, an NSAID drug used for arthritis and joint pain. Write the correct reagents/reactants next to the number of steps for each transformation.
which of the following compounds would be the most basic? A. p-methoxyaniline B. p-nitroaniline C. p-toluidine D. aniline E. All would have the same basicity
Detergent is a cleaning agent that is widely used in various purposes. One type of detergent is anionic detergent which is generally a sodium salt of a sulfonic acid such as sodium dodecylbenzene sulphonate. Write the correct reagent (not synthone) for I-IV ! The correct sodium dodecylbenzene sulphonate disconnection strategy is through pathway a or b ?
Give reagents necessary and show isolated intermediates for the synthesis below.
Write the products of the following sequences of reactions. Refer to your reaction roadmaps to see how the combined reactions allow you to navigate between the different functional groups. Note that you will need your old Chapters 611, Chapters 1518, and Chapter 19 roadmaps along with your new Chapter 20 reaction roadmap for these.
Which reagents are best used to produce 4-methyl-2-pentanol from a ketone? a. amins and trace acid, followed separetely H2/PD/C b. sodium cyanide followed by HCl c. sodium borohydridd followed by acidic work up d. hydrogen cyanide followed by HCl e. none of the above
Synthesise the target molecules drawn below using precursor chemicals within the following limitations: 1) ALL intermediates and reagents must be shown.2) Each molecule requires multiple step synthesis.3) You must also synthesize any organometallic reagents or ligands that you wish to use. a) Aspirin is a common pain killer that was developed by Bayer.
The compound shown below is treated with LDA at -78 degrees C, then after 15 minutes ethyl bromide is added slowly. Draw the products you would find after you work up the reaction.
Propose a synthesis of the cyclic five-membered target molecule shown below using propanal A as you only starting material. You may use any reagents of your choosing, but all of the carbon atoms in the final product MUST come from propanal A. Show all intermediates and reagents for each transformation (do not worry about the solvents). Hint: by counting the number of carbon in the product, we would need three molecules of propanal A.
How is an amide converted to an anhydride? Water with strong acid → PCl5 → Carboxylic Acid PCl5 → Water with strong acid → Carboxylic Acid Water with strong acid → Carboxylic Acid → PCl5 PCl5 → Carboxylic Acid → Water with strong acid What predominant electronic effect makes the amide a bad leaving group? + I - I + M - M
Scheme 1: Reagents: (a) acetic anhydride, sulfamic acid, 60°C,30min,91%; (b) Et3SiH,I2,0-5°C,30min,82%. 1) Draw the FULL, ARROW-PUSHING MECHANISM 2) Provide a verbalization of the mechanism for your reaction mechanism 3) What is happening at each step? What atom is nucleophilic? Which atom is electrophilic? Which bonds are made? Which bonds are broken? 4) Imagine you are trying to describe the reaction mechanism and I can't see your display - how would you describe the mechanism in a way that I know, that you know, what you are talking about.