What are the allosteric activators and inhibitors of de novo purine and pyramidine biosynthetic pathways?

Q: How may the covalent modification of a protein with a phosphate group alter its function?

A: Proteins are the polymers of the amino acids.

Q: What is the function of ubiquitin-conjugating enzyme?

A: Protein are degraded or proteolyzed by tagging it with Ubiquitin (76 amino acid protein).…

Q: How is palmitoylation inhibited?

A: Answer

Q: Design a protocol to clone, express, and study the structure, and activity of the enzyme…

A: Hex A Gene -- The Hex A gene which encodes the a lysosomal alpha subunit of hexosaminidase A…

Q: What does the complete hydrolysis of DATP and dTMP yield?

A: Deoxyadenosine triphosphate (dATP) is a nucleotide used in cells for DNA synthesis, as a substrate…

Q: What is the most significant difference between glycan synthesis and other biopolymer syntheses,…

A: DNA contains the genetic information that is used to make all the proteins of the body. The DNA is…

Q: What are aminoacyl-tRNA synthetases?

A: A protein or polypeptide sequence is biosynthesized during translation inside a live cell. The…

Q: What is Transpeptidation and why is it important?

A: A chemical reaction is a process that converts one or more substances into another substance.…

Q: What is the primary and secondary structure of ubiquitin-conjugating enzyme?

A: Ubiquitin is a 76 amino acid polypeptide that is found in a eukaryotic cell. ubiquitin is served…

Q: What advantages are there for synthesizing an inactive protein that must subsequently be activated…

A: When the proteins are synthesized into naive polypeptide then these are transferred to the…

Q: How do guanine and adenine nucleotides inhibit their own synthesis? How do they promote synthesis of…

A: Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are…

Q: Different Types of Regulation require by Catabolic and Anabolic Pathways?

A: Catabolic pathway: It refers to the series of reactions that requires degradation of complex…

Q: What are statins? What is their pharmacological function?

A: Cholesterol plays a role in normal cell and boock bdy function. However, very high levels can lead…

Q: From the result shown, what might be the histidine biosynthetic pathway (the order of enzymes)?

A: Histidine biosynthesis is an ancient metabolic partway present in bacteria, archaea, lower…

Q: What are the possible sources of errors or deviations between the theoretical and experimental pKa…

A: pKa value: pKa or Acid dissociation constant is also known as acidity constant or acid-ionization…

Q: How is b-galactosidase induced in cells?

A: The beta-galactosidase enzyme is found in lysosomes which are compartments within cells that…

Q: What are the advantages of synthesizing proteases as zymogens?

A: A zymogen, also called a proeznzyme, is an inactive precursor of an enzyme. A zymogen requires a…

Q: Explain the factors of trans-acting?

A: Gene expression depends upon various factors at molecular levels. There are various regulatory…

Q: What are the biomolecules that are used to biosynthesize a purine ring in the de novo pathway –…

A: Purine synthesis occurs in liver  by two pathways i.e  denovo synthesis  and salvage pathway. Denovo…

Q: What does guanylyl cyclase convert GTP into?

A: The study of chemical reactions that occurs within living organisms is called biochemistry. This…

Q: How is inosine monophosphate converted to AMP and GMP?

A: Inosine monophosphate (IMP) is a nucleotide and an important derivative of inosinic acid include the…

Q: What steps in the elongation cycle of protein synthesis require GTP hydrolysis? What role does it…

A: The translation is a process where mRNA was translated into a polypeptide chain or protein, where…

Q: What is denaturation? Give examples. What are the factors that affects the proteir synthesis?

A: Proteins are defined as an unbranched polymers which are made up of 22 amino acids. They are usually…

Q: How is ATCase regulated to generate precisely the amount of pyrimidines needed by the cell?

A: Aspartate transcarbamoylase (ATCase) catalyzes the first step of pyrimidine synthesis. It converts…

Q: Although aminoacyl-tRNA synthetases make few errors, occasionally an error does occur. How can these…

A: Each aminoacyl-tRNA synthetase is highly specific for a given amino acid. It will incorporate the…

Q: Why is penicillin such an effective inhibitor of the transpeptidase?

A: Transpeptidase is an enzyme that catalyzes a nucleophillic carbonyl substitution reaction necessary…

Q: What is an important difference between the biosynthesisof purine nucleotides and that of pyrimidine…

A: Introduction: A nucleoside and a phosphate make up nucleotides, which are organic molecules. They…

Q: What are caspases?

A: Caspases is the abbreviation of Cysteine-aspartic proteases that belong to the protease enzymes…

Q: How Are Thymine Nucleotides Synthesized?

A: Nucleotides are compounds composed of a phosphate and nucleoside.  They act as a monomer of the…

Q: What are the low-molecular-weight precursors needed for the de novo biosynthesis of the purine ring,…

A: Purine nucleotides are synthesized in the body via de novo synthesis or salvage pathway. Adenine and…

Q: What is isosterism and bioisostreism? How does this concept help in biotransformation of different…

A: In biology, drug designing is a major aspect. Drug specificity and effectivity are determined by…

Q: What are the reasons for glucuronide conjugation being a major phase II metabolic route?

A: Biotransformation is a chemical modification of biomolecules like nutrients, amino acids, toxins and…

Q: Mutations in the Galactose-1-Phosphate Uridyl Transferase Gene Can you use RFLP to identify this…

A: Mutation --It is an alteration in the sequence of  nucleotides in a genome of an organism , virus…

Q: Why are protein synthesis inhibitors typically broad spectrum?  What might prevent a protein…

A: Synthesis of all the proteins occur in a similar way that is every protein requires mainly these…

Q: What processes are involved in attaching ubiquitin to a target protein?

A: Amino acid chains are found in proteins. Proteins are folded with the aid of chaperones once they…

Q: Why cAMP is an important player for the regulation of enzymes by covalent modification mechanism?

A: A covalent modification can be defined as the mechanisms in which the covalent bonding of another…

Q: Azaserine inhibits amidotransferases. State the purine precursor that resembles azaserine. Which…

A: Cancer is the abnormal growth and multiplication of normal cells. Cancer cells divide rapidly.…

Q: What are posttranslational modifications?

A: The process of translation is defined as the production of the proteins by decoding the mRNA strand.…

Q: What is oligonucleotide adapter?

A: The oligonucleotide adapters are 20 to 25 nucleotides long DNA (deoxyribonucleic acid) molecules.…

Q: What is the properties of ribonuclease enzyme and describe what reaction it catalyzes?

A: Ribozymes, or  otherwise known as catalytic RNAs, were discovered around 15 years ago. They are…

Q: Why are structural analogs of sugar molecules (such as Oseltamivir and zanamivir) effective in…

A: The major surface glycoproteins used by the influenza virus in order to cause infections are…

Q: The biosynthetic pathway for the two amino acides E and H is shown schematically in the Figure…

A: Feedback inhibition is a cellular control mechanism in which an enzyme's activity is inhibited by…

Q: What is cisacting site ?

A: cis means " same side". The cis acting site acts as a site of DNA or RNA which helps in regulating…

Q: What is the purpose of the NaKATPase in a mammalian cell?

A: A phospholipid bilayer integrated with proteins forms the plasma membrane. It provides a durable…

Q: Which biochemical processes might be affected by a deficiency of thiamine?

A: The normal function of the human body relies on proper nutrition which can be derived from vitamins…

Q: What role does ubiquitin play in the degradation of proteins?

A: Proteins are macromolecules that exhibit varied functions in the cells. All enzymes are proteins and…