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- Cyclic-AMP stimulates which of the following? a) PKA b) PKC c) Ras d) RTKWould the following alterations to Src be oncogenic? Explain. (a) The deletion or inactivation of the SH3 domain. (b) The mutation of Tyr 416 to Phe.Would the following alterations to Src be oncogenic? Explain. (a) The mutation of Tyr 527 to Phe. (b) The replacement of Src residues 249 to 253 with the sequence APTMP.
- Explain the signifi cance of the observation that peptides such as fMet-Leu-Phe “activate” the phagocytotic (particle-engulfi ng) functions of mammalian leukocytes (white blood cells).Can anyone suggest a way of increasing phosphorylation of IKK alpha (Ser176/180)? Any potent phosphatase inhibitor in combination with TNF alpha?Utilizing Bentham's "Felicific Calculus" step-by-step, give a justification in practicing proper use of facemasks outdoors as a health protocol during this time of COVID-19.
- Which two coat proteins are involved in the bidirectional (two-way) trafficking of the KDEL receptor? COP II and clathrin COP I and COP II clathrin and dynamin COP I and clathrinWhich phase are initially inhibited by Sic1.Phosphorylation marks Sic1 for ubiquitinylation by theSCF ubiquitin-protein ligase and proteosomal degradation,releasing activated S phase CDKs that trigger onset of theS phaseThe egfr kinase independent transactivation of the ras pathway does require egfr. Explain this apparent contradiction.
- Phorbol esters have been observed to induce the transcription of AP-1–influenced genes. Explain how this processcould occur. What are the consequences of AP-1 transcription? What role does intermittent exposure to phorbol estershave on an individual’s health?How do loss of function mutations associated with Artemis (protein) cause their resulting phenotypes? Explain how genetically modified HSCs can treat these phenotypes.I come across a sentence "Myc mutations increase the lethality of Ras inhibitors", but am not sure if an increase in the lethality of Ras inhibitors is a good thing or bad thing. I should be grateful if the expert could help and advise.