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- Question 12 One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above and ensure that you click to reveal the transcript table. Then use the information in the table to answer the following question. PLEASE GIVE YOUR ANSWER AS A NUMBER ONLY, NO UNITS What is the size in base pairs of the CACNA1S transcript named CACNA1S-202? Answer: The size of the CACNA1S transcript named CACNA1S-202 is Blank ... base pairs.Question 26 What is true for CpG Islands: Question 26 options: stretches of a few hundred base pairs of DNA where cytosines are unmethylated are not associated with genes are not found around the promoters are associated with silenced genesQuestion 16: One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above and use the information and link-outs from the page to answer the following question. GIVE YOUR ANSWER AS A NUMBER ONLY, NO UNITS: What is the size in amino acid residues of the CACNA1S transcript named CACNA1S-202?
- question 26 What is true for CpG Islands: stretches of a few hundred base pairs of DNA where cytosines are unmethylated are not associated with genes are not found around the promoters are associated with silenced genesQuestion 14 One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above. Use the left-hand menu to view the sequence for CACNA1S, and answer the following question. ANSWER ONLY IN UPPERCASE LETTERS, NO UNITS. What are the last six nucleic acid bases of exon 1? Answer: The last six nucleic acid bases of CACNA1S, exon 1 are Blank ...Question 13 One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above and use the information and link-outs from the page to answer the following question. GIVE YOUR ANSWER AS A NUMBER ONLY, NO UNITS: What is the size in amino acid residues of the CACNA1S transcript named CACNA1S-202? Answer: The size of the CACNA1S transcript named CACNA1S-202 is Blank ... amino acid residues.
- Question:- 8. How can cells of the vertebrate immune system produce so many different immunoglobulins from a small set of genes?Question:- Protein kinase inhibitors have become a major focus for the development of molecularly targeted cancer therapies. Based on what you know from the development of Gleevec, what are at least two generalizable principles that apply to the development of all tyrosine kinase inhibitors? What is a potential pitfall of targeting a protein kinase for cancer treatment? (Relate back to Gleevec example - this answer should include three separate concepts – 2 principles, 1 limitation)Question:- 17. The optimal volume for blood-culture collection on adults is a. 20 mL of blood per bottle b. precisely 10 mL of blood in each of two bottles c. 20 mL of blood distributed betvveen two bottles but not exceeding 12 mL per vial d. dependent upon the patient's body weight
- QUESTION NO. 1 Cystic fibrosis is a frequent generic disease of Caucasians. The CF gene codes for a protein called the cystic fibrosis transmembrane conductance regulator (CFTR) which functions as a cAMP-regulated chloride channel. The protein has two membrane-spanning domains, two domains that interact with ATP, and one regulatory domain. The most common defect is in the gene for one of the ATP binding domains. The result is a protein that does not fold correctly in the endoplasmic reticulum, is not properly glycosylated, and is nor transported to the cell surface. Rather, it is degraded in the cytosol within proteasomes. Drugs that foster chaperone interaction with the mutant protein are a potential therapeutic approach. Chaperones A. are always required to direct the folding of proteins. B. when bound to protein increase the rate of protein degradation. C. usually bind to strongly hydrophilic regions of unfolded proteins. D. sometimes maintain proteins in an…Question 5. AP1 is a transcription factor and an important regulator of gene expression and cell proliferation. Dysregulation of AP1 function may lead to cancer. The fos gene codes for AP1. Below is an experiment in which the role of a micro‐RNA (miR‐7b) in the regulation of fos gene expression was studied. miR‐7b shows partial sequence complementarity to the 3′‐untranslated region of fos mRNA. A DNA fragment coding for miR‐7b RNA and another fragment coding for a micro‐RNA unrelated to fos mRNA were cloned into vectors, and the recombinant plasmids (designated si‐miR‐7b, samples 3 and 4, and si‐miR‐neg, samples 5 and 6, respectively, in Fig. 1) were introduced into mouse fibroblast cells. Non-transfected cells were used as controls (samples 1 and 2). Samples 2, 4, and 6, were treated with a chemical PMA that induces transcription of fos gene; samples 1, 3, and 5 were left untreated. Two hours after PMA treatment protein extracts were prepared from the cultures and were then…QUESTION 34 During fruit fly development, a transmembrane protein called Delta on the surfaces of presumptive neurons binds to a receptor, called Notch, on the surfaces of the immediately adjacent cells. This signals to the adjacent cells not to differentiate into neurons. This mode of signaling is: juxtacrine paracrine autocrine endocrine