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- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?. For several years, Hans Nachtsheim investigated an inherited anomaly of the white blood cells of rabbits. Thisanomaly, termed the Pelger anomaly, is the arrest ofthe segmentation of the nuclei of certain white cells. Thisanomaly does not appear to seriously burden the rabbits.a. When rabbits showing the Pelger anomaly were matedwith rabbits from a true-breeding normal stock,Nachtsheim counted 217 offspring showing the Pelgeranomaly and 237 normal progeny. What is the geneticbasis of the Pelger anomaly?b. When rabbits with the Pelger anomaly were matedwith each other, Nachtsheim found 223 normal progeny,439 with the Pelger anomaly, and 39 extremely abnormalprogeny. These very abnormal progeny not only haddefective white blood cells, but also showed severedeformities of the skeletal system; almost all of themdied soon after birth. In genetic terms, what do yousuppose these extremely defective rabbits represented?Why were there only 39 of them?c. What additional experimental evidence…Recessive maternal effect genes are identified in flies (for example)when a phenotypically normal mother cannot produce any normaloffspring. Because all of the offspring are dead, this female fly cannot be used to produce a strain of heterozygous flies that could beused in future studies. How would you identify heterozygous individuals that are carrying a recessive maternal effect allele? Howwould you maintain this strain of flies in a laboratory over manygenerations?
- DNA sequencing of your own two β-globin genes (one from each of your two Chromosome 11s) reveals a mutation in one of the genes. given this information alone, should you worry about being a carrier of an inherited disease that could be passed on to your children? What other information would you like to have to assess your risk?A condition known as icthyosis hystrix gravior appeared in a boy in the early eighteenth century. His skin became very thick and formed loose spines that were sloughed off at intervals. When he grew up, this “porcupine man” married and had six sons, all of whom had this condition, and several daughters, all of whom were normal. For four generations, this condition was passed from father to son. From this evidence, what can you postulate about the location of the gene?researchers have been able to clonemammals by fusing a cell having a diploid nucleus (i.e., a somaticcell) with an egg that has had its nucleus removed.A. With regard to maternal effect genes, would the phenotype ofsuch a cloned animal be determined by the animal that donatedthe egg or by the animal that donated the somatic cell? Explain.B. Would the cloned animal inherit extranuclear traits from theanimal that donated the egg or from the animal that donated thesomatic cell? Explain.C. In what ways would you expect this cloned animal to be similarto or different from the animal that donated the somatic cell? Isit fair to call such an animal a clone of the animal that donatedthe diploid nucleus?
- Explain at the biochemical or enzymatic level, the phenotypic consequencesof alleles incase of following cross. Rr (pink flower) x Rr (pink flower) (progeny are 1 RR (red flower) :2 Rr (pink flower): 1rr(white flower) how alleles contribute to a phenotype through metabolism.Gene Interaction and Epistasis Hair color is due to the presence of melanin. There are two types of melanin produced by melanocytes. One is eumelanin, which is responsible for black (homozygous), brown (heterozygous), and blond (recessive) hair colors. The other is pheomelanin, which is responsible for red hair color. During melanin synthesis, MCR1gene converts pheomelanin to eumelanin. However, a variant of the MCR1 gene (MCR1variant), prevents this conversion. A cross between a blond-haired mother and a red-haired father produced 100% brown-haired children. When they came of age, one child married a double heterozygote, and both were blessed with 7 children; 2 with black hair, 2 with brown hair, 1 with blond hair, and 2 with red hair. Using the 7-step method, determine the genotypes of the P1, the F1, and the F2s. BOX your answers (if handwritten) or HIGHLIGHT your answers (if encoded). STEP 1: ________________________________________________________ STEP 2:…For a certain gene in a diploid organism, eight units ofprotein product are needed for normal function. Eachwild-type allele produces five units.a. If a mutation creates a null allele, do you think thisallele will be recessive or dominant?b. What assumptions need to be made to answer part a?
- A company that offers PGD terms an embryo “normal and healthy” if it has 46 chromosomes. Why is this statement misleading? , Two famous male actors had twins using a surrogate mother who carried two embryos that hadbeen fertilized in vitro, one with one man’s sperm and the other with the other man’s sperm. In terms of genetics, how closely are the babies, a boy and a girl, related to each other if they have different fathers?A study of three generations in a family of a male colleague of the authors indicated that many of the man's blood relatives had died of cardiovascular accidents and coronary heart disease. Others died of other causes but were affected by high blood pressure. What are the implications of this information for the man in question? b. What information and help might a genetic counselor provide?. The production of pigment in the outer layer of seedsof corn requires each of the three independently assorting genes A, C, and R to be represented by at leastone dominant allele, as specified in Problem 64. Thedominant allele Pr of a fourth independently assortinggene is required to convert the biochemical precursorinto a purple pigment, and its recessive allele pr makesthe pigment red. Plants that do not produce pigmenthave yellow seeds. Consider a cross of a strain of genotype A/A ; C/C ; R/R ; pr/pr with a strain of genotypea/a ; c/c ; r/r ; Pr/Pr.a. What are the phenotypes of the parents?b. What will be the phenotype of the F1?c. What phenotypes, and in what proportions, willappear in the progeny of a selfed F1?d. What progeny proportions do you predict from thetestcross of an F1?