What if C-1 of the oxaloacetate were labeled instead, when would the label be released as CO2? (a) Fate of the carboxyl carbon of acetate unitHO-OxaloacetateMalateFumarateOxaloacetateHO-O00MalateFumarateSuccinate6-7710-4733Malate49OxaloacetateFumarateSuccinyl-CoA(b) Fate of methyl carbon of acetate unitO-S-ColSuccinate-S-CoAHO-O1st turn1st turnSuccinateHO-CCitrateHO-3rd turnSuccinyl-CoAHO-a-KetoglutarateCitrateIsocitrateно-a-KetoglutarateCitrateSuccinyl-CoAIsocitrateHO-Isocitratea-ketoglutarateO(100₂)O00₂)(00₂)(CO₂)(00₂)(CO₂)½ Totalmethyl ClabelOOxaloacetateHO-O-OMalateFumarateHO-G0-7-7MalateOxalcacetateFumarate0-8-s-coAHO-923Malate29SuccinateFumarate02999Oxaloacetate2nd turnHO-0-8--0SuccinateSuccinyl-COA2nd turn110-Succinate0-8-s-cCitrate10-4th turnSuccinyl-CoAa-Ketoglutarate,CitrateHOIsocitrateHO-a-KetoglutarateSuccinyl-CoACitrateHOIsocitrate O(100₂)Isocitratea-Ketoglutarate(00₂)(CD)(00₂)↑(CO₂),All labeledcarboxyl carbonremoved by thesetwo stepsTotalmethyl Clabel

Oxaloacetate is a four-carbon compound, and carbon-1 (C-1) refers to the first carbon atom in the…

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Biochemistry

What if C-1 of the oxaloacetate were labeled instead, when would the label be released as CO2?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

What if C-1 of the oxaloacetate were labeled instead, when would the label be released as CO₂?

(a) Fate of the carboxyl carbon of acetate unit
HO-
Oxaloacetate
Malate
Fumarate
Oxaloacetate
HO-O
00
Malate
Fumarate
Succinate
6-77
10-47
33
Malate
49
Oxaloacetate
Fumarate
Succinyl-CoA
(b) Fate of methyl carbon of acetate unit
O-S-Col
Succinate
-S-CoA
HO-O
1st turn
1st turn
Succinate
HO-C
Citrate
HO-
3rd turn
Succinyl-CoA
HO-
a-Ketoglutarate
Citrate
Isocitrate
но-
a-Ketoglutarate
Citrate
Succinyl-CoA
Isocitrate
HO-
Isocitrate
a-ketoglutarate
O
(100₂)
O
00₂)
(00₂)
(CO₂)
(00₂)
(CO₂)
½ Total
methyl C
label
O
Oxaloacetate
HO-O-O
Malate
Fumarate
HO-G
0-7-7
Malate
Oxalcacetate
Fumarate
0-8-s-coA
HO-9
23
Malate
29
Succinate
Fumarate
029
99
Oxaloacetate
2nd turn
HO-
0-8--0
Succinate
Succinyl-COA
2nd turn
110-
Succinate
0-8-s-c
Citrate
10-
4th turn
Succinyl-CoA
a-Ketoglutarate,
Citrate
HO
Isocitrate
HO-
a-Ketoglutarate
Succinyl-CoA
Citrate
HO
Isocitrate O
(100₂)
Isocitrate
a-Ketoglutarate
(00₂)
(CD)
(00₂)
↑
(CO₂),
All labeled
carboxyl carbon
removed by these
two steps
Total
methyl C
label

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Step 1: Oxaloacetate

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