What is the likely mechanism of nucleophilic substitution for attached alkyl halide?

Q: Draw structures for the carbonyl electrophile and enolate nucleophile that react to give the enone…

A: enolate attacks the carbonyl electrophile and forms enone  Generally this is resembles to aldol…

Q: Explain why hydroxide ion catalyzes the reaction of piperidine with 2,4-dinitroanisole but has no…

A: In the reaction of piperidine with 2,4-dinitroanisole, the rate determining step is the removal of…

Q: lease explain the mechanism for the ring opening of epoxide by reaction with nucleophile in base

A: Epoxides are called the cyclic ethers. The epoxide rings are very stable. When a nucleophile attacks…

Q: Rank the following compounds in order of increasing reactivity in nucleophilic addition.

A: Nucleophilic addition reactions are generally given by carbonyl compounds.  Therefore, aldehyde and…

Q: Friedel-Crafts acylation formed by attack at the meta positions of Nitrobenzene. (-NH2 and-OH) act…

A: In the Friedel-crafts acylation reaction, the electrophile is (RCO)+ that attacks the benzene ring…

Q: Choose the best explanation of why the hydroxy group is an o,p-director in electrophilic aromatic…

A: why the hydroxy group is an o,p-director in electrophilic aromatic substitution reactions is given…

Q: Explain the Mechanism of Tautomerization ?

A: In this question, we will explain the mechanism of Tautomerization.  You can see details explanation…

Q: Why is the presence of acid necessary in the reaction of carbonyl compounds with certain…

A: Reaction of carbonyl (suppose acetone) with nucleophile like 2,4-dinitrophenyl hydrazine follows…

Q: Select the nucleophile and electrophile needed in order to synthesize the product shown.

A: By seeing the product , we can directly select the electrophile and nucleophile.

Q: Show how the m-bromobenzonitrile can be synthesized from benzene:

A: Benzene is an aromatic compound. It consists of a six membered cyclic ring having alternate double…

Q: Explain how you would test the relative reactivities of 1‐butanol vs. 2‐butanol in a nucleophilic…

A: relative reactivities of 1‐butanol vs. 2‐butanol in a nucleophilic substitution with sodium bromide…

Q: Show how enols, enolate ions, andenamines act as nucleophiles

A:

Q: Explain advantages and disadvantages of Direct enolate alkylation ?

A: Direct enolate alkylation: In this reaction the α hydrogen is replaced by alkyl group resulting in…

Q: Explain the mechanism of Epoxidation of an Alkene with a Peroxyacid ?

A: Concept Introduction: The epoxidation of an alkene is the conversion of the C=C  double bond to an…

Q: Which electrophile is most likely to undergo a 1,2-hydride shift during an electrophilic aromatic…

A: Introduction : We have to tell the structure which is most likely to undergo 1,2 -hydride shift .

Q: What is the full reaction mechanism for the rection between tetraphenylcyclopentadienone, maleic…

A: This reaction is an example of Diels Alder reaction . Now we have to find out the mechanism for the…

Q: How common electron-donating and electron-withdrawinggroups affect both the rate of reaction of a…

A: The substitution of an atom or group of atom through an electrophile is termed as electrophilic…

Q: Carboxylic acids are lowest in reactivity towards nucleophilic substitution. Why? (Consider the…

A:

Q: How to determine the relative basicity of nitrogen heterocycles ?

A: Heterocyclic compounds are aromatic hydrocarbons with one or two hetero atoms like O or N. Some well…

Q: Explain the effect of the structure of the alkyl halide on elimination through E1 and E2.

A:

Q: Like other strong nucleophiles, triphenylphosphine attacks and opens epoxides. The initial product…

A: Mechanism for the above reaction is,

Q: Draw the mechanism of the favorable reaction of NH3 and sodium ethoxide through acid-base reaction.

A: In a favorable reaction, NH3 will act as an acid and Sofium ethoxide as a base. The mechanism is…

Q: Why do we have "orto" and "para" regioselectivity in bromination and nitration in electrophilic…

A: In Aromatic  compounds pi electron density more so acts as pi electron donor to electrophile .…

Q: Give the products (if any) expected from the treatment of each of the compounds with ozone followed…

A: The solution is as follows :

Q: Please draw and explain the mechanism of the formation of epoxide via intramolecular SN2 reaction of…

A: Halohydrins when treated with strong base (such as hydroxide anion) result in the formation of…

Q: Draw structures for the carbonyl electrophile and enolate nucleophile that react to give the enone…

A:

Q: Illustrate the Opening of Epoxide Rings with Strong Nucleophiles ?

A: Epoxides are cyclic ethers which contains a three atom ring that approximates an equilateral…

Q: Explain the direct method of enolate alkylation ?

A: The enolate alkylation can be done by using strong bases as LDA or sodium amide.

Q: Why is the carbon bonded to halogen electrophilic? Indicate with arrows the direction of…

A: Carbon is less electronegative than halogen atom.  Halogen atom has greater tendency to attract…

Q: Why can aniline not be brominated directly to 4-bromoaniline?

A: In aniline, -NH2 group is both para and ortho directing group due to resonance effect. Since, the…

Q: Provide necessary carbonyl compound and phosphonium ylide to yield the alkene. What type of ylide…

A: Given,

Q: Give the major product and the stepwise reaction mechanism for the following acid catalyzed epoxide…

A: Answer:- This question is answered by using the simple concept chemical reaction of epoxides with…

Q: Which of the following dicarbonyl species would also be successful nucleophiles in the…

A: The reactions in which the two molecules combine together and form a single molecule is known as…

Q: Which one undergoes the fastest reaction with methanol in acidic condition?

A: We have given the four ketone that are going to react with methanol in acidic medium. The rate…

Q: Friedel-Crafts acylation

A:

Q: Draw the first intermediates after the pericyclic decarboxylation of 3-oxobutanoic acid with heat.

A: In this question, we will draw first intermidiate after pericyclic decarboxylation.  You can see…

Q: Describe which products will be formed as a result of the reaction with the nitronium ion in the…

A: Alkoxy group on the benzene is a ring activating group which directs the incoming electrophile…

Q: Show how enols, enamines, and enolate ions act as nucleophiles. Give mechanismsfor acid-catalyzed…

A: Given nucleophiles,               Enols, enamines, and enolate ions.

Q: Could you explain the main characteristics and occurences in nucleophilic acyl substitution? Thank…

A: Nucleophilic acyl substitution describe a class of substitution reaction involving nucleophiles and…

Q: Order of reactivity towards nucleophilic substitution reaction of the compounds

A: Order of the reactivity towards nucleophillic substitution reaction of the compound

Q: Which of the following compounds is the most reactive in the nucleophilic aromatic substitution…

A: In general benzene undergo electrophilic aromatic substitution reactions  When electron…

Q: Could you summarize the main characteristics of nucleophilic acyl substitution?

A: A type of substitution reaction combining an acyl group and a nucleophile is known as nucleophilic…

Q: State Mechanism for Benzylic Bromination ?

A: Interpretation-  To state the mechanism of the Benzylic bromination  -    Introduction-  In the…