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1. y-linked recessive
2. autosomal recessive
3. autosomal dominant
4. X-linked dominant
5. Pleiotrophic
6. X-linked recessive
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- Attached are three pedigrees. For each trait, considerwhether it is or is not consistent with X-linked recessiveinheritance. In a sentence or two, indicate why or why not.A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?Frank and Susan both have freckles but they're firstborn son Lawrence does not demonstrate the characteristics. What are the most likely genotype of Frank Susan and Lawrence?
- In each of the following pedigrees (C, D) by inspection, determine the mode of inheritance involved. Indicate the possible genotypes of all individuals in all the pedigrees.The accompanying pedigree is for a rare, but relativelymild, hereditary disorder of the skin.a. How is the disorder inherited? State reasons for youranswer.b. Give genotypes for as many individuals in thepedigree as possible. (Invent your own defined allelesymbols.)c. Consider the four unaffected children of parentsIII-4 and III-5. In all four-child progenies from parentsof these genotypes, what proportion is expected tocontain all unaffected children?(picture added)Unattached earlobes (E) are dominant over attached earlobes (e) [Figure (a) and (b)]. If a woman with unattached earlobes and a man with attached earlobes have children, what percentage of their children has the possibility of having unattached earlobes if the mother is homozygous for the trait?
- A woman with achondroplasia (a dominant form of dwarfism) anda phenotypically unaffected man have seven children, all of whomhave achondroplasia. What is the probability of producing such afamily if this woman is a heterozygote? What is the probabilitythat the woman is a heterozygote if her eighth child does not havethis disorder?Which of the following mode of inheritance most likely to representthe pedigree showing the pattern of inheritance of a rare disorder? Autosomal dominant X linked dominant Autosomal recessive X linked recessiveAssuming complete penetrance, which type of inheritance pattern isconsistent with the pedigree shown here? a. Autosomal recessiveb. Autosomal dominantc. X-linked recessived. X-linked dominant
- What is the differencebetween dominant allele andrecessive allele?In humans, a rare dominant disorder known as nail-patella syndromecauses abnormalities in the fingernails, toenails, and kneecaps.Researchers have examined family pedigrees with regard to thisdisorder and have also examined the blood types of individualswithin each pedigree. (A description of blood genotypes is foundin Chapter 4.) In the following pedigree, individuals affected withnail-patella disorder are shown with filled symbols. The genotypeof each individual with regard to ABO blood type is also shown.Does this pedigree suggest any linkage between the gene thatcauses nail-patella syndrome and the gene that causes blood type?Below is a partial pedigree of hemophilia in the British RoyalFamily descended from Queen Victoria, who is believed to bethe original “carrier” in this pedigree. Analyze the pedigree andindicate which females are also certain to be carriers. What is theprobability that Princess Irene is a carrier?