a. What is the genotype of the mother? b. What is the genotype of the father? c. What are the genotypes of the five children" 41. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? ?? 11 a. Autosomal recessive only b. Autosomal dominant only c. X-linked recessive only d. X-linked dominant only e. All of the above are possible. 42. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? 11 a Autosomal recessive only b. Autosomal dominant only c X-linked recessive only d X-linked dominant only e. All of them are possible. 43. If the phenotype followed in the pedigree below is X-linked recerve, then the genetype of 11-2 is a homozygous dominant b heterozygous chomozygous recessive dhemuzygous dominant e bemizygous recessive.

a. What is the genotype of the mother? b. What is the genotype of the father? c. What are the genotypes of the five children" 41. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? ?? 11 a. Autosomal recessive only b. Autosomal dominant only c. X-linked recessive only d. X-linked dominant only e. All of the above are possible. 42. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? 11 a Autosomal recessive only b. Autosomal dominant only c X-linked recessive only d X-linked dominant only e. All of them are possible. 43. If the phenotype followed in the pedigree below is X-linked recerve, then the genetype of 11-2 is a homozygous dominant b heterozygous chomozygous recessive dhemuzygous dominant e bemizygous recessive.

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Description: Generationa. What is the genotype of the mother?b. What is the genotype of the father?c. What are the genotypes of the five children"41. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree?11a. Autosomal

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 21QP: Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic...

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Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linked
A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?
A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?
A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?
Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.
Analysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?
Now assume that the pedigree shown in question 1 shows the inheritance of a rare genetic disease. a) The disease is most likely autosomal dominant b) The disease is most likely autosomal recessive c) The disease is equally likely to be either autosomal dominant or autosomal recessive, but cannot be x-linked d) Cannot be determined from the information given
I will be adding two questions here because I asked two of the same questions twice by accident earlier. A man and a woman do not have hemophilioa, but the womans father did. (Hemophilia is X-linked recessive). a) What is the probability that they will have a child with hemophilia? b) Is it possible for any of their daughters to be affected? Explain. A cross between a horse homozygous for red hair and a horse homozygous for white hair results in offspring with the coat colour called roan. When you look at the fur of the roan offspring you see both red and white hairs. What type of inheritance best explains this? a) blending inheritance b)codominance c)incomplete codominance d)multiple alleles
1-Gigantism is being traced in a family through a pedigree. Its mode of inheritance is thought to be autosomal recessive. You examine the pedigree and decide that the mode of inheritance is not correct. What is the correct mode of inheritance? 2-Provide 2 pieces of evidence for the mode of inheritance selected for Gigantism. (i.e.- Individual 45 is afflicted and passed it on to all of her offspring, indicating that it is dominant. Or there is a gendered pattern of inheritance seen when Individual 99 passed it on to only his female offspring.)
Circle any inheritance patterns that could explain this pedigree. Assume individuals marrying into the family do not have a mutant allele. Please refer to the image attached. A) Paternally imprinted B) Maternally imprinted C) Maternal inheritance D) Autosomal recessive E) Autosomal dominant F) X-linked recessive G) X-linked dominant
1. Hair or fur length in cats is controlled by a single, autosomal gene; the short hair-allele is dominant to the allele for long hair. Hair color is produced by a different gene which is located on the X chromosome. One allele for this sex-linked gene produces yellow, while an alternate allele produces black fur color; individualswhich are heterozygous for these alleles are calico or tortiseshell in color.If a long-haired, black male is mated with a calico female homozygous for short hair what kind of kittens will be produced in the Ej generation? Give both genotypes and phenotypes; express the genotypes bothsymbolically and in words. Label answers clearly!!
QUANTITATIVE Recall that hemophilia is an X-linked recessive disease. If a woman with hemophilia had children with a man without hemophilia, what is the chance that their first child will have the disease? What is the chance that their first child will be a carrier?