Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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What is shotgun sequencing and what technological advance was required to make this happen? 

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INTRODUCTION:- Shotgun sequencing involves randomly breaking up DNA sequences  into lots of small pieces and then reassembling the sequence by looking for regions overlap'

-This method was used by fred sanger and his colleagues  to sequence small genomes such as viruses and bacteria.

-In whole genome shotgun sequencing the entire genome is broken up into small fragments of DNA for sequencing.

-These fragments are often of varying sizes, ranging from 2-20 kilobases  to 200-300 kb.

-These fragments are sequenced to determine the order of the DNA bases, A,C,G and T.

-The sequenced fragments are then assembled together by  computer programs that find where fragments overlap. 

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