When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.

Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...
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When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.
Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
= 2
(dimerization)
phosphorylated cytoplasmic tails of RTKS serve as
docking platforms for various intracellular proteins
= 4
involved in signal transduction
neighboring RTKS to associate with each other
= 5
each RTK in the dimer phosphorylates multiple
= 3
tyrosines on the other RTK
activation of the tyrosine kinase activity in these RTKS
= 1
through phosphorylation
Transcribed Image Text:Gene targets DNA Cell proliferation, survival, migration, and differentiation CYTOPLASM NUCLEUS Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V leads to the formation of cross-linked dimers = 2 (dimerization) phosphorylated cytoplasmic tails of RTKS serve as docking platforms for various intracellular proteins = 4 involved in signal transduction neighboring RTKS to associate with each other = 5 each RTK in the dimer phosphorylates multiple = 3 tyrosines on the other RTK activation of the tyrosine kinase activity in these RTKS = 1 through phosphorylation
When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events
in the correct order from 1st to the last step.
RTK
Tyrosine kinase
domain
Phosphorylated tyrosines
PLASMA MEMBRANE
MAP kinase
signaling
JAK/STAT
signaling
PI3K/AKTI
signaling
Gene targets
DNA
Cell proliferation, survival,
migration, and differentiation
CYTOPLASM
NUCLEUS
Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V
leads to the formation of cross-linked dimers
2
(dimerization)
II
000
000
Transcribed Image Text:When a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step. RTK Tyrosine kinase domain Phosphorylated tyrosines PLASMA MEMBRANE MAP kinase signaling JAK/STAT signaling PI3K/AKTI signaling Gene targets DNA Cell proliferation, survival, migration, and differentiation CYTOPLASM NUCLEUS Drag and drop options on the right-hand side and submit. For keyboard navigation. SHOW MORE V leads to the formation of cross-linked dimers 2 (dimerization) II 000 000
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