When Rb is mutant: |the generic intercellular pathway is activated. CDK-G1 cyclin is activated and ubiquitinates Rb CDK-G1 cyclin is inactivated and Rb becomes active active Rb protein is phosphorylated by CDK-G1 cyclin and becomes inactive inactive or missing Rb protein is phosphorylated and becomes active active Rb protein becomes a transcription factor and activates genes inactive or missing Rb protein becomes a transcription factor and represses genes active Rb protein inactivates transcription factors and represses genes inactive or missing Rb protein releases transcription factors that activate genes

When Rb is mutant: |the generic intercellular pathway is activated. CDK-G1 cyclin is activated and ubiquitinates Rb CDK-G1 cyclin is inactivated and Rb becomes active active Rb protein is phosphorylated by CDK-G1 cyclin and becomes inactive inactive or missing Rb protein is phosphorylated and becomes active active Rb protein becomes a transcription factor and activates genes inactive or missing Rb protein becomes a transcription factor and represses genes active Rb protein inactivates transcription factors and represses genes inactive or missing Rb protein releases transcription factors that activate genes

Biology Today and Tomorrow without Physiology (MindTap Course List)

5th Edition

ISBN:9781305117396

Author:Cecie Starr, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Christine Evers, Lisa Starr

Chapter7: Gene Expression And Control

Section: Chapter Questions

Problem 12SQ

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The cell enters g1 and cyclin D binds with CDK4/6 Increases in cyclin D expression prevent p21/p27 from inhibiting cyclin E/CDK2 Rb is hypo-phosphorylated E2F is no longer repressed and induces expression of E2F and cyclin E The cell enters S phase and cyclin A binds to CDK2 cyclin A binds to CDC 2 > Cell enters G2 and cyclin B binds CDC 2 Cell enters M phase and proliferates Put these in the correct order from 1-8
The cell enters g1 and cyclin D binds with CDK4/6 Increases in cyclin D expression prevent p21/p27 from inhibiting cyclin E/CDK2 Rb is hypo-phosphorylated E2F is no longer repressed and induces expression of E2F and cyclin E The cell enters S phase and cyclin A binds to CDK2 cyclin A binds to CDC 2 > Cell enters G2 and cyclin B binds CDC 2 Cell enters M phase and proliferates Rb is hyperphosphorylated Upsteam signaling pathways lead to increase of expression of Cyclin D put in correct order from 1-10
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