Which of the following could be classified as an oncogene? None are possible oncogenes A mutant of MAP kinase that was active with or without being phosphorylated All are possible oncogenes A mutant of MEK with significantly reduced enzyme activity A mutant cAMP phosphodiesterase that made it super-active
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Which of the following could be classified as an oncogene?
- None are possible oncogenes
- A mutant of MAP kinase that was active with or without being phosphorylated
- All are possible oncogenes
- A mutant of MEK with significantly reduced enzyme activity
- A mutant cAMP phosphodiesterase that made it super-active
Step by step
Solved in 3 steps
- Which of the following classes of oncogenes would likely be druggable with a small molecule (select all that apply)? A. Nuclear hormone receptor B. RAS C. Serine/Threoine Kinase D. Transcription Factor E. Receptor Tyrosine KinasePut the following steps in the correct orderedsequence.a. kinase cascadeb. activation of a transcription factorc. hormone binds transmembrane receptord. expression of target genes in the nucleuse. Ras molecular switchWhich of the following are regulators of Cdks? Choose all that apply. There are 3 correct answers. You will LOSE points (from the total correct) for incorrect answers. This is to discourage guessing. licensing proteins activating kinases cyclins inhibiting kinases Rb Mad and Bub proteins
- In a patient with a constitutively active receptor tyrosine kinase that increases the activity of PI3K, the administration of a drug that increases PTEN expression will likely inhibit tumorigenesis because; Group of answer choices PTEN prevents growth factor binding to RTK PTEN competitively inhibits the catalytic subunit of PI3K PTEN dephosphorylates PIP3 PTEN inhibits the dimerization of the regulatory subunit of RTKsThis TSG targets beta-catenin for degradation and inhibits the Wnt signaling pathway but when it is silenced, predisposes patients to Familial Adenomatous Polyposis and colorectal cancer. Group of answer choices APC WT1 p53 ARFCyclin D/cdk 4,6 inhibits retinoblastoma protein (Rb) binding to...., which ultimately affects gene expression. cycling-dependent kinase tramscription factor E2F p53 oncogenes
- 1. EGF interacts with blank to activate the MAP kinase cascade? G protein coupled receptor; receptor Tyrosine kinase; serine/threonine kinase; cdk 2. When a trimetric G protein is activated by gpcf? The three subuni8of the G protein remain tightly associated with each other; the GDP bound to the a subunit is phosphorylated to form bound GTP; it dissociates into a free b subunit as an ay subunit; noneWhich of the following would be expected to inhibit PKC activation by a GPCR ligand? phospholipase C inhibitor cAMP phosphodiesterase inhibitor Ras inhibitor MAP kinase inhibitorProtein phosphorylation is commonly involved with all of thefollowing except(A) activation of receptor tyrosine kinases.(B) activation of protein kinase molecules.(C) activation of G protein-coupled receptors.(D) regulation of transcription by signaling molecules.
- The product of the human papillomavirous oncogene E7promotes cancer by emhancing expression of telomere inhibiting DNA damage repair pathways binding to Rb protein and preventing itd function ubiquitinating the tumor suppressor p53This phosphatase removes an inhibitory phosphotyrosine phosphate from serine protein kinase, mentioned in question 6, which activates kinase. What phosphatase is it? This is what question 6 says....This is the serine protein kinase that when activated in a complex cyclin, controls onset of mitosis and M-phase of the cell cycle. 1. Cyclin A/B 2. Wee 1 3. TOR (Target of Rapmycin) 4. Cdk1 5. none of the these ***I believe the answer is Cdk1 for number 6, but I could be wrongWhich of the following types of mutations would be most likely to cause cells to undergo apoptosis (programmed cell death)? One that increases the affinity of p21 for Cdks One that decreases the affinity of Rb for the transcription factor E2F One that decreases the ability of p53 to bind to DNA One that causes p53 to be constitutively phosphorylated