Which of the following best describes the phenomenon of actin filament treadmilling? O Treadmilling refers to the transportation of actin filaments by motor proteins from one location to another. Actin filament treadmilling does not require ATP hydrolysis. Treadmilling occurs when actin subunits are removed from the minus end (also called pointed end) and at the same time more actin subuntis are added at the plus end (also called barbed end). Actin filament treadmilling only occurs at very high concentration of free actin monomer.

Which of the following best describes the phenomenon of actin filament treadmilling? O Treadmilling refers to the transportation of actin filaments by motor proteins from one location to another. Actin filament treadmilling does not require ATP hydrolysis. Treadmilling occurs when actin subunits are removed from the minus end (also called pointed end) and at the same time more actin subuntis are added at the plus end (also called barbed end). Actin filament treadmilling only occurs at very high concentration of free actin monomer.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter8: Muscle Physiology

Section: Chapter Questions

Problem 2TAHL

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What would be the consequence for actin filament assembly/disassembly if a mutation prevented actin’s ability to bind ATP? What would be the consequence if a mutation prevented actin’s ability to hydrolyze ATP?
What would be the consequences of actin filament assembly/disassembly if a mutation prevented actins ability to bing ATP
Which of the following are differences between the assembly processes of intermediate filaments versus that of actin microfilaments? A. New subunits are added internally to the intermediate filament rather than at the ends B. Assembly requires GTP rather than ATP C. Intermediate filaments are assembled from multiple tetramers rather than from monomers. D. A and B E. A and C
ATP within actin subunits is hydrolyzed after assembly into a filament but before disassembly from a filament. in theprocess of assembly into a filament. in the process of disassociation from a filament after disassociation from a filament
Which of the following proteins plays a important role in the geometry of sarcomere and in sarcomerogenesis? GAPDH Colligen Titin Utropitin urease
The sarcoplasmic reticulum Ca2+-ATPase, pumps 2 mol Ca2+ out of sarcomeres per mol ATP hydrolyzed.(a) Given the following steady-state concentrations and a membrane potential of 65 mV (inside negative), calculate ΔG for the following activetransport process at 37 °C and pH = 7.4:2Ca2+(in) + ATP + H2O → 2Ca2+(out) + ADP + Pi + H+ATP = 2.6 mM, ADP = 210 μM, Pi = 5.1 mM, Ca2+(in) = 32 mM,Ca2+(out) = 2.2 mM(b) In active muscle the pH can drop below 7.4. Is the reaction above moreor less favorable under these conditions?(c) The activity of the Ca2+-ATPase is regulated reversibly under normalconditions to maintain homeostatic concentrations of Ca2+ inside thesarcomere. However, in a rare genetic disorder, irreversible activation ofthe Ca2+ -ATPase can occur. Assuming 37 °C, pH = 7.4, and the steadystate concentrations for ATP, ADP Pi, and Ca2 +(out) given in part (a),calculate the minimum [Ca2 +] inside a sarcomere that has irreversibly activated Ca2 +-ATPase (i.e., the Ca2 +-ATPase…
Actin filaments have a defined polarity. What is filament polarity? How is it generated at the subunit level?
Neurofilament proteins assemble into long, intermediate filaments , found in abundance running along the length of nerve cell axons. The C-terminal region of these proteins is an unstructured polypeptide, hundreds of amino acids long and heavily modified by the addition of phosphate groups. The term “polymer brush” has been applied to this part of the neurofilament. can you suggest why?
Which of the following describes an F-actin microfilament? A flexible, helical filament composed of two strands assembled from G-actin 13 protofilaments composed of heterodimers with a hollow core a flexible filament composed of 13 interwoven protofilaments Eight tetramers twisted into a rope-like filament
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If you were to watch muscle tissue contract: Under a light microscope, would you see the muscle fibers get narrower, or the striations get thinner? Explain. At the EM level, focusing on one sarcomere, you would be able to see a region of thick filaments overlapping two regions of thin filaments. Use the structure of the thick filaments to explain how ONE region of thick filaments is able to pull in microfilament in two opposite directions (both toward the center of the sarcomere).
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