Which of the following could result in the continuous activation of a cell signalling pathway? A mutation resulting in the inactivation of a protein phosphatase. A mutation resulting in the inactivation of adenylyl cyclase that forms CAMP. A mutation resulting in a receptor tyrosine kinase being unable to form a dimer. A mutation resulting in a ligand gated ion channel being unable to open.

Which of the following could result in the continuous activation of a cell signalling pathway? A mutation resulting in the inactivation of a protein phosphatase. A mutation resulting in the inactivation of adenylyl cyclase that forms CAMP. A mutation resulting in a receptor tyrosine kinase being unable to form a dimer. A mutation resulting in a ligand gated ion channel being unable to open.

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter15: The Endocrine System

Section: Chapter Questions

Problem 1SQ: __________ are molecules released from a signaling cell that have effects on target cells. a....

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What is the role of negative feedback in a cell-signalling pathway? To switch off a signal once of the output reaches a certain threshold To trigger the degradation of upstream signalling components To amplify the output of a signal To ensure a signal is transient
All cells of a multicellular organism may not respond in the same wayto a particular ligand (signaling molecule) that binds to a cell surfacereceptor. The difference in response may be due toa. the type of receptor for the ligand that the cell expresses.b the affinity of the ligand for the receptor in a given cell type.c. the type of signal transduction pathways that the cell expresses.d. the type of target proteins that the cell expresses.e. all of the above.
A cell expresses a transmembrane protein that is cleaved at the plasma membrane to release an extracellular fragment. The fragment binds to receptor proteins on nearby cells and activates signaling pathways resulting in altered gene expression patterns in the cells. What form of intercellular signaling does this represent? Contact-dependent? Paracrine? Synaptic? Endocrine? Autocrine?
Can a cell have multiple responses to one stimulus? A) Yes, such as a second messenger activating a kinase and a transcription factor B) No, one stimulus = one response. C) Yes, but only if the stimulus activates two different types of receptors, like a GPCR and a protein kinase receptor at the same time
A cell within organ A expresses a protein that is secreted from the cell and travels through the organism’s blood stream to a cell on a distant organ B. The protein binds to a receptor protein on the cell surface of organ B and activates an intracellular signaling pathway resulting in altered gene expression patterns in the cells. What form of intercellular signaling does this represent? Contact-dependent? Paracrine? Synaptic? Endocrine? Autocrine?
When a signaling molecule binds to a receptor located in the cell membrane, the signal / information is carried further into the cell via the receptor. The signal / information will lead to some type of change inside in cells in response to the signal it received. What this change is depends on the type of signaling molecule that binds to the cell (but may also depend on the type of cell that the signaling molecule binds to). In some cases, the change that takes place in the cell will be rapid and take a few seconds off that the signaling molecule binds to the receptor until the change takes place (fast signaling pathway). In some cases the change will take much longer, perhaps several hours from the time the signaling molecule binds to the receptor until the change occurs in the cell (slow signaling pathway). Explain how the signal path would be be able to look when it is fast and what it could look like when it is slow.
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A drug binds to a receptor and causes an immediate change in the electrical signaling or excitability of that cell, without activating another signaling molecule. What type of receptor is this drug most likely binding to? G-protein coupled receptor (GPCR) Ligand-gated ion channel Enzyme-coupled receptor Intracellular receptor Voltage-gated ion channel
Received information is called a transduced signal because: this process often has many steps of information conversion. it is then converted into other electrical forms. it is then converted into other chemical forms. many different molecules form a signaling cascade. it is then converted into other chemicals during metabolism.
Which of these is NOT a response that occurs when an intercellular chemical signal binds to a membrane-bound receptor? 1. Enzymes at the inner surface of the cell are directly activated. 2. Ion channels open or close. 3. Enzymes add phosphate groups to certain proteins in the cell. 4. The chemical signal and receptor bind to DNA in the nucleus. 5. Activated G proteins activate enzymes that produce intracellular messengers.
Which of the following is true of signal transduction mediated by protein tyrosine kinases production of cAMP phosphoinositides are activated arrestins compete with G-proteins phosphorylation of tyrosine residues
When signals bind to the protein receptors, it depends if the receptor is found on the nuclear or cell membrane. genes are turned on or off. gates open up and then there is a cellular response, such as an action potential. the receptor changes its shape in order to bind the signal and to function.