Which of the following is/are incorrect about the differences between globular and membrane proteins? 1. Membrane proteins are embedded in a lipid environment while globular proteins are solvated by water. 2. The surface of membrane proteins are likely to feature amino acid residues with hydrophobic side chains. 3. Globular proteins, because of their environment, do not have amino acid residues with hydrophobic side chains. 4. No membrane protein has any portions that are exposed to water. 2 and 3 O 1 O 3 O 4 O 3 and 4
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- In what way do proteins embedded in a membrane differ structurally from soluble proteins?In the "fluid " _______ cell membrane model, lipids are organized in a ________ arrangement, such that _______ portions of the lipids are exposed to either the interior or exterior of the cell, while the lipid portions are sandwiched in the middle of the membrane. As part of the cell membrane, a main function of peripheral proteins is to provide _________ , while a main function of proteins is to provide _________ . Other cell membrane molecules include a compound called __________, which functions to provide fluidity to rigid membranes and rigidity to fluid membranes; and surface carbohydrates, which function in the membrane not to provide energy, but instead to provide _________ _____ . Aminophospholipids (including PE and ) move to the inner leaflet of the membrane, by an enzyme known as the ._______ A main function of the cell membrane is to be very selective as to what is able to cross through, a condition known as a barrier.Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer.a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues thatcan be in each α-helixes for them to be long enough to span the bilayer?
- Protein folding is critical for function because the properties of a protein arise from its overall shape and the distribution within that shape of the various amino acid side-chains. Which of the following statements about protein three-dimensional structure are correct? 1) the folding pattern of a protein is ultimately determined by its amino acid sequence. 2) proteins tend to fold in such a way that the hydrophobic amino acids are buried in the interior, while hydrophilic amino acids are exposed at the surface. 3) the chemical interactions within a protein molecule that support its overall folded structure are mostly covalent C-C (carbon to carbon) bonds between amino acid side-chains. 4) the overall folding pattern/shape of a protein molecule is termed its primary structure. 5) during evolution, the three-dimensional structure of a protein is often more strongly conserved than its amino acid sequence. More than one answer might be rightIdentify the following membrane associated proteins based on their structure: (a) tetramers of identical subunits, each with six membrane spanning α helices; (b) trimers of identical subunits, each with 16 β sheets forming a barrel like structure.The tertiary structure of a protein is the 3-dimensional folding of the polypeptide chain. What types of bonds support the folding of proteins into this level of protein structure? Also, how do these bonds/interactions impact how a protein folds and its surface properties? Can the tertiary structure of a protein depend on the type of cell system used for synthesis? Explain.
- The plasma membrane of E. coli is about 75% protein and 25% phospholipid by weight. How many molecules of membrane lipid are present for each molecule of membrane protein? Assume an average protein Mr of 50,000and an average phospholipid Mr of 750. What more would you need to know to estimate the fraction of the membrane surface that is covered by lipids?Besides lipid molecules, cell membranes also contain many different types of proteins, each with specific functions. In the following table, select the common type of membrane protein in the right-hand column that each statement in the left-hand column describes. The choices on the Type of Membrane Protein are the same for theFunction of the Membrane ProteinWhat are lipid rafts? Describe the molecular components and interactions that occur in forming lipid rafts and explain how specific membrane proteins become concentrated in these rafts as opposed to diffusing freely throughout the membrane.
- Multi-adhesive matrix proteins form adhesive bridges between what type of components or structures? Give an example of such an ECM protein?Which of the following statements about alpha-helix and beta-sheet structure are true? More than one answer is correct. -they are aspects of protein secondary structure. -they are maintained by hydrogen-bonding interactions within the polypeptide backbone. -most proteins fall into one of two categories: those composed entirely of alpha-helix, and those composed entirely of beta-sheet. -in both alpha-helix and beta-sheet, each amino acid (at position n) interacts with another amino acid at position n+4. -alpha-helix contains only hydrophobic amino acids, while beta-sheet contains only hydrophilic amino acids. More than one answer is correct I am confusedWhich categories of amino acid would you expect to find on the surface of a soluble protein, and which would you expect to find in the interior? What distribution of amino acids would you expect to find in a protein embedded in a lipid bilayer