Which of the following statements about de novo purine synthesis is true? (A) Purine nucleotides are formed by separately synthesizing the phosphorylated ribose and the purine ring and then joining them together. (B) GMP is formed first and is used as a precursor to form AMP. (C) The synthesis of AMP from inosinate is driven forward by ATP hydrolysis. (D) GMP synthetase uses NADPH and glutamine to modify the inosinate ring to form GMP. (E) Replacement of the C-1 PPi on PRPP with an amine is required to construct the purine ring on the ribose sugar.

Which of the following statements about de novo purine synthesis is true? (A) Purine nucleotides are formed by separately synthesizing the phosphorylated ribose and the purine ring and then joining them together. (B) GMP is formed first and is used as a precursor to form AMP. (C) The synthesis of AMP from inosinate is driven forward by ATP hydrolysis. (D) GMP synthetase uses NADPH and glutamine to modify the inosinate ring to form GMP. (E) Replacement of the C-1 PPi on PRPP with an amine is required to construct the purine ring on the ribose sugar.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 20P: Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy...

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