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- What is the rate limiting step in catecholamines synthesis ?What functional group interactions between the cate- cholamines and adrenoceptors are most likely? Which functional groups are considered pharmacophores of catecholamines?What is the similarity between the long form of the dopamine type 4 receptor and the more active form of the COMT enzyme?
- How many high-phosphoryltransferpotential molecules are required to synthesize phosphatidylethanolamine from ethanolamine and diacylglycerol? Assume that the ethanolamine is the activated component.Under what conditions might receptor up-regulation occur? receptor down-regulation?What biochemical changes are required to convert tyrosine to (a) norepinephrine and (b) epinephrine?
- How does Merkel’s receptor function in the body. Give an example on how it functions.What is the structue of dopamin, and suggest the binding interactions of dopamine with the receptor. Draw a suggested model for the required interactions for agonistic and antagonistic activty in dopamine receptor.Why is cAMP a “second messenger”?