Why can't stoichiometry be applied to grams of chemicals and only to moles or molecules of chemicals?  Please give a well-detailed explanation as well as example :)

Introductory Chemistry: A Foundation
9th Edition
ISBN:9781337399425
Author:Steven S. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Donald J. DeCoste
Chapter9: Chemical Quantities
Section9.3: Mass Calculations
Problem 1CT: ur lab partner has made the observation that we always measure the mass of chemicals in lab, but...
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Why can't stoichiometry be applied to grams of chemicals and only to moles or molecules of chemicals? 

Please give a well-detailed explanation as well as example :) 

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