Why does it make sense that AMP is a positive allosteric regulator of PFK-1 enzyme activity, whereas citrate is a negative allosteric regulator of PFK-1, ie., what do these metabolites signal in the cell when their levels are high?
Musculoskeletal System
The musculoskeletal system, also called the locomotor system, is an organ system that gives humans and animals the ability to move using their muscular and skeletal systems. It provides stability, form, support, and movement to the body. The skeleton is composed of bones (skeleton), muscles, cartilage, tendons, ligaments, joints, and other connective tissue that supports and binds tissues and organs together. The musculoskeletal system is subdivided into two broad systems, such as the muscular system and the skeletal system.
Skeletal structure
The skeletal system is the core framework of the human body. The skeletal structure comprises bones and connective tissue, including cartilage, ligaments, and tendons. The skeletal structure of our body acts as a support structure. It maintains the body's shape and is responsible for its movement, blood cell formation, protection of organs, and mineral storage. The skeletal system is referred to as the musculoskeletal system.
BIOC 384
Regulation of the Glycolytic Pathway
Q9.3: Why does it make sense that AMP is a positive allosteric regulator of PFK-1 enzyme activity, whereas citrate is a negative allosteric regulator of PFK-1, ie., what do these metabolites signal in the cell when their levels are high?
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