Why is it necessary to resolve Chiral pharmaceuticals why can't we just use racemic versions in the resolution of ibuprofen experiment?

Q: Bridgehead complexes don’t undergo SN2 reaction as compared to open chain system. Prove it with 3…

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Q: Would you expect the Rf value for tryptophan to be closer to that of leucine or arginine? Why?

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Q: Explain the process of Calculating Enantiomeric Excess ?

A: The absolute difference between the mole fraction of two enantiomers is termed as enantiomers.

Q: Specifically how would the resolution of ibuprofen experiment change if a student used…

A: Why R isomer of phenyl ethyl amine can not be used as a resolving agent for the racemic mixture of…

Q: If we did the paperclip activity with a cup of isopropyl alcohol instead of water, would you expect…

A: If the paperclip activity is done with a cup of isopropyl alcohol instead of water, different…

Q: The pKa of Cu2+ is 10.7 in aqueous solution. Would you expect the pKa of Cu2+ to be higher, lower,…

A: pKa = - log Ka

Q: B When a chiral compound is dissolved in water the observed rotation is 8.4°. If the specific…

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Q: Solution A contains 9 g of pure (-)-fructose was diluted to 500 mL with water and placed in a…

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Q: IR stretches occurs at the lowest energy?

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Q: The (R) enantiomer of a pure compound has optical rotation [a], 25 = 60.0⁰. If a sample is 66.6% R…

A: The R enantiomer of a pure compound has optical rotation of 60.0° . A sample is 66.6 % R and 33.3…

Q: Search the standard of Bendroflumethiazide and its tablets USP. •What kind of method applied in the…

A: "Since there are multiple sub-parts in this question and it is not mentioned that which one has to…

Q: 12. Using a suitable example, explain (using structures) what is meant by a meso compound. Draw the…

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Q: You have two unlabeled bottles, one contains ribitol and one contains arabitol but you do not know…

A: Spectroscopy is a technique which is used to identify the structure of the organic compound. 1HNMR…

Q: How many atoms share the unpaired electron in semiquinone?

A: The structure of semiquinone is shown below. The semiquinone is a radical, it means that it has one…

Q: What strategy did McGregor & Hughes use to differentiate stereoisomers of nerolidol by GCXGC-MS?

A: When the molecules have the same bonding pattern of the groups besides having the same molecular…

Q: Explain why fac' isomer shows orlv one methyl signal whereas 'mer' isomer shows three methyl signals…

A: Let's first understand the structure of the ligand. ligand: 2-(m-tolyalazo)pyridine   This ligand…

Q: The interconversion of cyclic anomer from alpha to beta configuration is called ______.

A: The interconversion of cyclic anomer from alpha to beta configuration is called mutarotation.…

Q: A. Distinguish the amine component from the coupling component in the given azo dye. B. Sketch the…

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Q: (-)-Cholesterol has a specific rotation of -32o. A mixture of (+)- and (-)-cholesterol was analyzed…

A: The sign of rotation is +, means S enantiomer is present in excess.  That is rotation for R(-) is is…

Q: How would the experiment of resolution of ibuprofen change if a student instead used racemic…

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Q: any Vitamin C destroyed by heating

A: In this question we have to explain that any vitamin C destroyed by heating and also we know about…

Q: Why is it necessary to resolve chiral pharmaceuticals (why cant we just use racemic versions)? What…

A: The separation of two enantiomers is called a resolution.

Q: When one of the enantiomers of butan-2-ol is placed in a polarimeter, the observed rotation is 4.05°…

A: Given, The mass of butan-2-ol is 6.0g. The volume of butan-2-ol is 40.0mL. The length of the…

Q: What will be the residue and what will be formed at cooler portion of test tubes if the tube…

A: Sugar: Sugar belongs to carbohydrate, which contains energy. It is white crystalline solid with…

Q: write equation and draw a well labeled outline showing how the resolution of ibuprofen process…

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Q: Define heterolytic cleavage.

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Q: Explain why fac' isomer shows onlv one methyl signal whereas 'mer' isomer shows three methyl signals…

A: Transition metal complexes or coordination metal complexes are formed by arrangement of groups of…

Q: The encircled part of the TGA indicates loss of...

A: The variation of the mass of the substance with respect to the change in temperature values observed…

Q: A unknown sample gave a specific rotation of 0 when placed in a polarimeter. What conclusion(s) can…

A: In organic chemistry the Specific rotation means it is the property of a chiral chemical compound.

Q: Why does the mobile phase in reversed phase (C18) HPLC needs to be acidic?

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Q: The (-) enantiomer of a compound has a specific rotation of [a] = 123°. What rotation, a, will be…

A: Since you have posted multiple questions, we are entitled to answer the first only.

Q: justify the ingridients of benadryl cream

A: The Benadryl cream is actually an itch stopping cream. It is used to relieve itching and pain…

Q: Which separation technique is the most specific and offers the highest protein purification…

A: Chromatography is one the best technique for separation of molecules. It is based on the principle…

Q: The optical rotation of a sample was found to be 0.24° when the concentration was 0.60 g in 10 mL of…

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Q: In polarimetry when the sugar is heated for 60 mins instead of 30 mins hwat happens to the extent of…

A: The electronic configuration of the Carbon atom is 1s22s22p2. It can form a maximum of 4 bonds with…

Q: There are almost 500 naturally occurring variants of hemoglobin. Hemoglobin X is a hemoglobin…

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Q: ind the isoelectric and zwitter ion of lysine, show the steps

A: Given the isoelectric and zwitter ion of lysine

Q: What is the commercial use of ibuprofen? 2. What are the important criteria of a good resolving…

A: 1) Commercial use:          It is used to relieve pain from various conditions like - headache,…

Q: Is it possible to resolve a racemic mixture of 1-phenylethylamine with (-)-malic acid?

A: Find answer next steps

Q: If you did not get a 100% pure sample of (+)-phenylsuccinic acid from Polarimetry experiment, how…

A: Using resolution process, phenyl succinic acid can be purified. The enantiomers are first treated…

Q: 1) Compare between three steps for Kjeldahl method for determination of protein?I

A: INTRODUCTION: Kjeldahl method is defined as the method which is used for quantitative determination…

Q: If we give same sample to three different students in the same lab, why the result of melting point…

A: Melting point is the temperature at which the solid substance melts and converted into liquid phase.…

Q: Provide an illustration of resolution of a racemate mixture using diasteromer formation.

A: We have to illustration of resolution of racemate mixture using diasteromer formation.

Q: What will be the optical rotation of a mixture of equal portions of (+)-MTPA and its enantiomer?

A: Racemic mixture  A mixture of equal proportions of two enantiomers, or substances with dissymmetric…

Q: A researcher isolated 10 g of a Natural Product from a local plant. In an attempt to determine the…

A: 1) Polarimeter used by researcher to obtain the reading.   A polarimeter is  used to measure the…

Q: Question 1 Why should absorbance outside the standard curve be used to determine the unknown…

A: A question based on analytical process that is to be accomplished.

Q: Bridgehead complexes don't undergo SN2 reaction as compared to open chain system.prove it with three…

A: In bridging system (a), chlorine is bonded at bridgehead carbon and in SN2 reaction, nucleophile…

Q: In Diels-Alder experiment you refluxed the reactants for 30 minutes. What is refluxing and why is it…

A: Diels-Alder reaction is carried out by refluxing the reactants in xylene .Both of the reactants are…