You have a 5'(A/T)–3' SNV potential. Draw out to explain why using the sense strand and template strand would both yield the same color if you were heterozygous at this SNV location. (The color is red, by the way.) How do vou distinguish between sex-linked and limited expression in male traits in pedigrees?
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- Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?AaBbCc x AaBbcc How would you characterize this kind of relationship between the genes: A-B- (gray); A-bb (yellow); aaB- (black); aabb (cream) The CC and Cc genotypes allow color according to the expression of the A and B alleles. However, the cc genotype results in albino rats regardless of the A and B alleles presentSusan’s grandfather was deaf, and passed down a hereditary form of deafness within Susan’s family as shown in Figure Q19–12.A. Is this mutation most likely to be dominant or recessive?B. Is it carried on an autosome or a sex chromosome? Why?C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected, and 7 unaffected). In comparing these 11 SNP results, how long a haplotype block would you expect to find around the critical gene? How might you detect it?
- Pigeons have long been the subject of genetic studies. Indeed, Charles Darwin bred pigeons in the hope of unraveling the principles of heredity but was unsuccessful. A series of genetic investigations in the early 1900s worked out the hereditary basis of color variation in these birds. W. R. Horlancher was interested in the genetic basis of kiteness, a color pattern that consists of a mixture of red and black stippling of the feathers. He carried out the following crosses to investigate the genetic relation of kiteness to black and red feather color (W. R. Horlancher. 1930. Genetics 15:312–346). Cross Offspring kitey × kitey 16 kitey, 5 black, 3 red kitey × black 6 kitey, 7 black red × kitey 18 red, 9 kitey, 6 black a. On the basis of these results, propose a hypothesis to explain the inheritance of kitey, black, and red feather color in pigeons. (Hint: Assume that two loci are involved and some type of epistasis occurs.) b. For each of the preceding crosses, test your hypothesis by…Produce a pedigree diagram to convey the information shown. Gill, has come along to the Genetic Clinic with her younger sister, Charlotte. They have been invited because Charlotte’s youngest child, Jamie, who is 10 months old, is experiencing multiple, recurring parallel infections. Jamie has two very healthy older siblings, the eldest is his sister, Penny, and the middle child is his brother, Charlie. Gill’s youngest child, her son, Tom, is only 18 months old but has been in constant contact with the hospital since he was born. He has had recurrent bouts of pneumonia, bronchitis, otitis, conjunctivitis, and sinusitis. He often has diarrhoea and, due to the incredible strain on his small body, he is failing to thrive. Thankfully his medical team were thorough in their investigations, and he has just been diagnosed with X-linked agammaglobulinemia. Tom has two older siblings, the youngest of whom, Ella, was conceived as a twin, though IVF, but her twin died in utero at about 9 weeks…Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).
- DNA sequencing of your own two β-globin genes (one from each of your two Chromosome 11s) reveals a mutation in one of the genes. given this information alone, should you worry about being a carrier of an inherited disease that could be passed on to your children? What other information would you like to have to assess your risk?Neep help ASAP. A red flowered plant was crossed with a blue flowered plant and produced all purple flowered plants. When the purple flowered plants were crossed with each other they produced 5 red plants, 5 blue plants, 20 deep purple plants, 20 light lilac plants, and 30 purple plants How many genes are involved in the color production? Assume that red color is caused by an A allele and blue color by a B allele and determine the likely genotype of the plants in the F2 generation.What is the most likely order of the linked genes R, S, and T if the distance between R and S is 22 cM, the distance between S and T is 8cM, and the distance between R and T is 14 cM? A. R S T B. T R S C. Cannot be determined D. S T R
- Multiple crosses were made between true-breeding lines of black and yellow Labrador retrievers. All the F1 progeny were yellow. When these progeny were intercrossed, they produced an F2 consisting of 121 yellow, 9 black and 30 chocolate. What epistatic ratio and what kind of epistasis is approximated in the F2? Propose a biochemical pathway for coat color in Labrador retrievers based on the type of epistasis. Correlate each genotype with the phenotype that would occur in your pathway. Also show the frequency of each genotype. A-B- A-bb aaB- aabbYou have already localized the genes to the same chromosome by deletion mapping, and now decide that the best way to accomplish the mapping is to conduct two simultaneous three-point testcross experiments. The genes you are investigating are as follows: N = round leaves, n = notched leaves; H = smooth stems, h = hairy stems; R = purple flowers, r = red flowers; B = grey seeds, b = black seeds; and Y = green pods, y = yellow pods. Earlier experiments you have done already established that gene B is in the middle of this gene cluster, so you design both three-point test crosses to include that gene. Cross #1 is designed as RrHhBb x rrhhbb while cross #2 is NnBbYy x nnbbyy. The results of both crosses are given in the table below. Based on the information given, determine the arrangement of these five genes including the position of each allele in the heterozygous fly and the distances between each pair of genes. (Hint: treat each experiment separately, knowing that gene B is in the…Examine the two pedigrees shown in Figure Q7–3.One results from deletion of a maternally imprinted auto-somal gene. The other pedigree results from deletion of apaternally imprinted autosomal gene. In both pedigrees,affected individuals (red symbols) are heterozygous forthe deletion. These individuals are affected because onecopy of the chromosome carries an imprinted, inactivegene, while the other carries a deletion of the gene. Dottedyellow symbols indicate individuals that carry the deletedlocus, but do not display the mutant phenotype. Whichpedigree is based on paternal imprinting and which onmaternal imprinting? Explain your answer.