НО Ph' Ph NO2 Ph Ph Ph NH, HN. CI HN NH, of Br Ph' Ph HN, NH2 HN. NH2 H. OH HO HO HN, NH2 HN, NH2 Carbuterol

Q: Propose structural formulas for compounds A and B.

A: Various mechanisms are used in organic chemistry. The mechanism tells which bonds are formed and…

Q: (1) Which is the most basic amine and which is a secondary amine? (2) Which can undergo hydrolysis?…

A: Given (1) Which is the most basic amine and which is a secondary amine? (2) Which can undergo…

Q: Show how the reagent for Step 6 can be prepared from salicylic acid (2-hydroxybenzoic acid).…

A: The step 6 in the synthesis of sildenafil is the reaction between aromatic acid and aromatic amine.

Q: Propose a mechanism for reaction (2).

A: The given reaction is one of the nucleophilic aromatic substitution reactions. The aromatic ring is…

Q: CyHN ch is worth 10 por intermediate #2 from intermediate #1 and for intermediate #3 going to the…

A: DCC is used for coupling of carboxylic acid and amine.

Q: Rank and explain the following compounds in order of increasing acidity. ( indicate 1 more most…

A: We have to rank and explain the following given compounds in order of increasing acidity as follows…

Q: One of the heptanedione isomers below has a pka of approximately 9 rather than 20. Which isomer?…

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Q: (b) Give two suggestions of chemical modification of the below compound to make it more drug-like.…

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Q: Primary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by…

A: The major drawback of the method in which primary amine synthesis is done by using the reaction of…

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Q: Is fenfluramine chiral? If so, which of the possible stereoisomers are formed in this synthesis?

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Q: A solution of acetone [(CH3)2C=O] in ethanol (CH3CH2OH) in the presence of a trace of acid was…

A: Ketones react with alcohol in the presence of acid H+ to form acetal. Acetal contains two alkoxy…

Q: 18. Indicate whether the compound shown below is aromatic. 19. aromatic not aromatic Which compound…

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Q: 30) Show an increase in the order of the acidity for the following aromatic acids: (i) p-ethyl…

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Q: A solution of acetone [(CH3)2C = O] in ethanol (CH3CH2OH) in the presence of a trace of acid was…

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Q: Is toremifene chiral? If so, which of the possible stereoisomers are formed in this synthesis?

A: The compound having a carbon atom that is bonded to four different atoms or groups is referred as…

Q: Pyridine undergoes electrophilic aromatic substitution preferentially at the 3 position as…

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Q: он N=N N- а. b. H3CO LOCH3 H3CO. LOCH3 N. ÓCH3 С.

A: The detail solution is given below

Q: Following is an outline of a synthesis of the bronchodilator carbuterol, a beta-2 adrenergic blocker…

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Q: -NH2 CI CI A B C Aniline Imine Aminal Stan and Kyle have observed a reaction between the aniline…

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Q: To prepare butanoic acid from 1-propanol, which sequence of reagent(s) is/are best employed? A (1)…

A: Sceheme 1: Step 1 : propanol reaction with PBr3 results bromo propane. Step 2 : Bromo propane…

Q: Following is a series of anorexics (appetite suppressants). As you study their structures, you will…

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Q: Primary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by…

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Q: Rank the following compounds in order of increasing basicity: I. p-nitroaniline II.…

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Q: Phenacetin is an analgesic compound having molecular formula C10H13NO2. Once a common component in…

A: Structure of phenacetin from its 1H NMR and IR spectra is

Q: REACTION MECHANISMS (Reactions of aryl Provide the mechanisms (use MarvinSketch, or (Reactions of…

A: Reaction 1 : formation of nitrosonium ion

Q: Propose a structure for a compound C,H12O2 that dissolves in dilute NaOH and shows the followin 'H…

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Q: Propose a synthesis for ibutilide starting with aniline, methanesulfonyl chloride, succinic…

A: Given:

Q: I. Explain in your own words any mistake in the following given. The same construct of sentences…

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Q: According to the Evan's pKa table, phenol has a pKa of 9.95. p-Nitro and m-nitrophenol have pKas of…

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Q: 2. (a) This problem deals with the acidity of amines, not their basicity (or the acidity of their…

A: "Since you have posted a question with multiple sub-parts, we will solve the first three subparts…

Q: It is a component of nylon 66. a. Phthalic acid b. Lauric acid O c. Benzoic acid d. Adipic acid e.…

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Q: Propose a mechanism for the conversion of F to toremifene

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Q: Benzoic acid reacts with conc. HNO3 and conc.H2SO, to give a. o-nitrobenzoic acid b. p-nitrobenzoic…

A: Given,  Choose the correct product of the reaction = ?

Q: Q1:- Arrange the following compounds of each set in order of decreasing acidity ? Explain your…

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Q: Tertiary aromatic amine reacts with NaNO2 / HCI at (0 C Oto give deep brown precipitate of: * a.…

A: Answer

Q: Propose ONE reasonable synthesis from the options below. Provide a selective synthesis

A: acetone is carbonyl compound Carbonyl adjacent hydrogen atom more acidic in nature so in presence of…

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Q: Match the descriptions to the structures. OH OH ABA AHA ACA OH AIA H₂N less acidic substituted…

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Q: (a) Write structures for compounds A and B involved in the following chemical sequence. Molecule A…

A: All three reactions are Micheal addition (1,4-addition) reaction. a) answer

Q: Aliphatic amines are more basic than ammonia, whereas aromatic amines are less basic than ammonia.…

A: Aliphatic amines are more basic than ammonia, whereas aromatic amines are less basic than ammonia is…

Q: 8. As mentioned in exercise 5, carboxamides are compounds used for cancer treatments, and studies of…

A: Here we have to write the intermediate products formed during the given sequence of reactions.

Q: Propose an explanation for the fact that the trifluoromethyl group is almost exclusively meta…

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Q: between the compounds or not. (i) Compounds A and B, using UV-Vis spectroscopy with a detection…

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Q: When N,N-dimethylaniline is treated with chlorine and aluminum trichloride, ortho and para products…

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Q: iv)Propose a mechanism (curved arrow formalism) for the reaction of the  synthesis of a sulfonamide…

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Q: Compound x (CeH12 reacts with BH3 followed by H2O2. NaOH, H20 to yield Compound Y (CgH140) as the…

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.