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  • Role Of Sacsin In Lysosomal Transport

    877 Words  | 4 Pages

    replacement of an asparagine with aspartic acid in the α4-α5 loop near the edge of the HEPN dimer interface2. Performing a pulldown assay with a mutated HEPN construct that retains the property of JIP3 binding, but is unable to dimerize would indicate that HEPN interacts with JIP3. However, this construct was found to destabilize HEPN folding through the loss of two polar contacts and the introduction of a charge at the dimer interface. Furthermore, the expression of this mutant HEPN domain in a bacterial system

  • Assignment ( Hatters ) ( Transthyretin )

    932 Words  | 4 Pages

    Figure 1. Three-dimensional cartoon style structure of transthyretin (TTR) showing two monomers/one dimer of the dimer-of-dimers quaternary structure (monomers pink and orange) at the binding interface. Stick style top view of AG10 (blue) highlighting two binding sites per tetramer and key binding serine and lysine residues S117 and K15 of TTR (green). All monomers

  • Receptor Dimers: Heterodimers and Homodimers. Receptor dimers are receptor complexes formed by two

    600 Words  | 3 Pages

    Receptor Dimers: Heterodimers and Homodimers. Receptor dimers are receptor complexes formed by two covalently or non-covalently bound receptor subunits. Receptor dimerisation regulates signal transduction in various receptors or alter pharmacology. The Enzyme linked transmembrane receptors (they dimerise only when bound by a ligand to cause activation via autophosphorylation), The G-protein coupled receptors (GPCRs) (they form constitutive dimers to mask the E.R retention motif on the C- terminal)

  • D-Dimer Test Paper

    495 Words  | 2 Pages

    Labs D-dimer test will be performed. Elevated levels could be indicative of PE. D -dimer values Normal: Less than 250 micrograms per liter (mcg/L) Less than 1.37 nanomoles per liter (nmol/L) Labs D-dimer results are also age dependent. Persons less than 50 years of age should be evaluated on an age appropriate scale. 2. Imaging Computed Tomography scans, or CT scans, to look for blood clots in the lungs and legs. For this test, dye is injected into a vein in the arm. The dye makes the blood vessels

  • D-Dimer Test Lab Report

    288 Words  | 2 Pages

    Why am I having this test? The D-dimer test is used to help diagnose conditions that cause abnormal or excessive blood clotting, such as thrombosis or disseminated intravascular coagulation (DIC). This test may also be used to monitor treatment for a blood clotting disease. What is being tested? A blood sample is required for this test. It is usually collected by inserting a needle into a vein. What kind of sample is taken? A blood sample will be taken. How do I prepare for this test? There is no

  • Supramolecular Architecture Of Rhodopsin Captured By The Afm Image And Available Crystallographic Data

    774 Words  | 4 Pages

    neighboring rhodopsin molecules within the dimer as well as between distinct rows of dimers (Liang et al., 2003). This model suggested that the intradimeric contacts defining primary dimer interface involve transmembrane helices 4 (TM4) and 5 (TM5), whereas the formation of rhodopsin dimer rows is facilitated by the interaction between helices 1 (TM1) and 2 (TM2). Interestingly, a structure of squid rhodopsin, solved soon after, agreed with TM4/TM5 dimer very well (Murakami and Kouyama, 2008). Different

  • Essay on Experiment on Photocromism and Piezochromism

    1363 Words  | 6 Pages

    Introduction This experiment investigates an oxidative coupling reaction in an to synthesise triphenylimidazole dimer from 2,4,5-triphenyl-1H-imidazole. The resulting compound was investigated for both photochromic and piezochromic properties by way of formation of a stable radical, utilizing visual observations and UV-Vis as a means of distinction. Both the oxidative coupling reaction and the dimers interaction with light are depicted in the reactions in figure 1. Figure 1: Oxidative Coupling

  • Contamination In Non-Template Control Case Study

    1069 Words  | 5 Pages

    Optimization of reaction to reduce formation of primer dimers. Technical note no.LC1/99.). The presence of multiple bands in same well or so-called primer ladders is primarily a product of non-specific amplification or contamination, and are a result of the multimerization of the primers, where primers bind

  • Collagen is the predominant protein in animal bodies, constituting approximately 30% of the total

    500 Words  | 2 Pages

    size, approximately about 1000 amino acids. Network-forming collagen is type IV collagens found in basement membranes and type VIII and X collagens. This class of collagen forms net-like structures in which monomers associate at the C-termini to form dimers and at the N-termini to form tetramers. In addition to these end-to-end interactions, the triple-helical domains intertwine to form supercoiled structures. FACIT collagen stands for fibril associated collagen with interrupted triplehelice, which includes

  • UV Radiation induces a mutation Essay

    1269 Words  | 6 Pages

    To deduce if UV Radiation induced a mutation in the DNA of Serratia Marcescens and prevented the production of the red pigment called Prodigiosin. Hypothesis: Maybe the disappearance of red color in Serratia Marcescens is caused by the UV light which induces mutations in its DNA and is known as a common mutagen. Prediction: If UV light mutates the DNA of Serratia Marcescens then the red pigment colonies of the bacteria will no longer be produced. Independent Variable: Ultra Violet Radiation