Helicobacter pylori

Abstract Helicobacter pylori is a bacterium responsible for worldwide chronic bacterial infection in human. At least half of the world’s population host H. pylori that causes various gastric pathological outcomes with some leading to gastric cancer. The infection by this bacterium has directly or indirectly caused an impact on economic and general well-being of the people; hence, there is an urgent need to discover diagnostic markers that could be utilized for future development of diagnostic kits

Helicobacter pylori Introduction Helicobacter pylori, also known as H. pylori, is a spiral bacterium that lives inside the human stomach. H. pylori likes the acidic environment that the stomach provides and evidence has linked it to a variety of minor gastrointestinal illnesses. H. pylori causes inflammation in the lining of the stomach and is involved in 90% of stomach and intestinal ulcers. H. pylori also has an apparent cause to the development of adenocarcinoma, a common stomach cancer. J. Robin

Pathology and Pathophysiology: Helicobacter pylori is found commonly in the mucosal lining of the stomach and the duodenum without penetrating epithelium because its adaptability to the highly acidic and low pH environment. However, occasional or persistent presence has been suggested, (Figure 2) H.pylori DNA was successfully isolated from other locations in the body, such as atherosclerotic plaques and oral cavity, which is not surely confirmed whether its presence due to true colonization for those

The history of Helicobacter pylori goes back to 1875 when German scientists found the spiral shaped bacteria in the stomach linings of patients (“Helicobacter Pylori,” Wikipedia). However, Helicobacter pylori, also known as H. pylori, was officially discovered in 1982 by Barry Marshall and Robin Warren when they ended up leaving petri dishes incubating over Easter weekend (“Helicobacter pylori,” Wikipedia). After returning to the petri dishes after five days they discovered they had unintentionally

Helicobacter pylori and Gastric cancer Helicobacter pylori is a small, microaerophilic gram negative rods that regularly colonize the human stomach (Strausbaugh et al., 2002). It is one of the common bacterial pathogen that is found in the stomach of almost half of the world’s population (Zhao et al., 2014) and such well adaptation or successful long lasting colonization of H. pylori in to the human stomach is achieved by the combination of different factors, which addresses different challenges

Helicobacter Pylori at Tight Junctions Prior to the isolation of Helicobacter pylori (H. pylori} by Robin Warren and Barry Marshall in 1982, it was theorized that peptic ulceration, an ailment first described in 1857 by William Brinton, stemmed from poor diet, tobacco use, and stress due to the failure to definitively identify a causative agent as well as the belief that the inhospitable environment within the human stomach resulted in its sterility (Tanenbaum 2005). Because physicians were ignorant

HELICOBACTER PYLORI Helicobacter pylori have been implicated in cases of chronic gastritis, peptic ulcer diseases( includes duodenal and gastric ulcers). Even though these diseases were linked to stress factors, in 1983, Australian microbiologists Warren and Marshall proved that gastritis and peptic ulcer diseases were infectious diseases caused by a bacterium (1). This bacterium has also been linked to gastric carcinoma and Mucosa associated lymphocyte (MALT) lymphoma (2) This organism was formerly

Helicobacter Pylori or H. Pylori is a type of bacteria that invades the body and infects the digestive tract. It was discovered around 1983 by Warren, a biologist and Marshall, a clinician. It is named because of the spiral shape that allows the bacterium to burrow itself deep within the mucosal layer of the stomach wall. This penetration of the stomach lining enables to the bacteria to protect itself against immune cells that would recognize the organism as an invader. In order to survive the

Helicobacter pylori is structurally small, gram negative rods which is microaerophilic in nature and has capability of colonizing regularly in human stomach (Strausbaugh et al., 2002). Due to such colonizing capability, it is regarded as one of the most common bacterial pathogen present in almost 50% of the world’s population (Zhao et al., 2014) and the reason behind such well adaptation or enduring of H.pylori in the Human’s stomach is due to the combined effects of several factors that addresses

1.1 Helicobacter pylori (H. pylori) infection in the world Helicobacter pylori (H. pylori), which was discovered in 1983 and is a spiral-shaped bacterium that is found in the gastric mucous layer or adherent to the epithelial lining of the stomach (B. J. Marshall & Warren, 1984). The infection of H. pylori is a common and significant public health problem. It affects more than half of the adult population worldwide (Parkin, 2004). In most individuals, H. pylori infection can be asymptomatic throughout