Oligodendrocyte

Expression of the long non-coding RNA Sox2ot during postnatal developmental of the rat brain Introduction Long non-coding RNAs (lncRNAs) make up a large portion of cellular transcripts in the mammalian transcriptome (Clark and Blackshaw 2014) . In all human transcripts, at least 10,000 non-coding RNAs are thought to be greater than 200 base pairs (bps) in length, with little to no coding capacity, and are therefore classed as lncRNAs (Zhu et al. 2013; Clark and Blackshaw 2014). In some cases, transcripts

Introduction Nociception is the sensation of pain which is normally a warning signal to brain in respond to a potential hazard. Generally noxious stimulations are detected by specialised high-threshold sensory neurons, which are refer to nociceptors. The signals are then transferred to an electrical potential and conducted to the brain via spinal cord. However sometimes abnormal nociception can lead to a moderate to severe pain although a noxious stimulus is missing. This kind of pain are usually

Recent epidemiological studies have linked mild traumatic brain injury as a risk factor for dementia. Estimated that 100 to 300 per 100,000 people seek medical attention for mTBI annually worldwide. Due to not all persons with mTBI seeking medical attention it is estimated that 600 per 100,000 have a mTBI annually. Epidemiological evidence suggests that moderate or severe traumatic brain injury (TBI) is an important risk factor for neurodegenerative diseases such as: Alzheimer’s disease, Parkinson’s

Introduction The history of Lorenzo’s Oil derived from one story, based on a young man named Lorenzo Odone and his parents will and dedication to help him survive and regain his loss of functions. It began at the age of five, when Lorenzo’s teacher’s first noted a bad behavioral change. After witnessing the behavioral change themselves, Lorenzo’s parents, Michaela and Augusto Odone, took it upon themselves to get Lorenzo tested. After being checked out by several doctors it was confirmed that Lorenzo

Understanding Spinal Cord Injuries Spinal cord injuries can be very devastating. First we will discuss the spinal cord's structure and function. Then we will tell you how the spinal cord is most commonly injured, along with some statistics involved and some signs of spinal cord injury. We will explain some changes to the body after spinal injuries. Finally we will talk about some of the research in helping spinal cord injury victims. The spinal cord is the final common pathway from the

specific. MiRNA are important element for proper nervous system function. These miRNA plays a crucial role for brain function. Any disruption in the miRNA processing mechanism would cause diseases like ataxia in Purkinje cells, multiple sclerosis in oligodendrocyte cells, Parkinson’s disease in dopaminergic cells, Alzheimer’s disease in α-calcium/calmodulin-dependent protein kinase type II (αCaMKII)-expressing neurons (16). Recent studies on systemic miRNA profiling of peripheral blood mononuclear cells

Introduction The normal function of the central and peripheral nervous systems depend highly on the successful functionality of afferent and efferent neurons. Neurons are cells that have the ability to transmit sensory and motor messages throughout the body. These signals are promoted by electrically insulating myelin sheaths that surround the axons of neurons. These sheaths are produced by Schwann cells and other glial cells. When a neuron is damaged, a communicative circuit is compromised and

I. TITLE: Mechanisms of EBV Latent Membrane protein trafficking to exosomes II. BACKGROUND AND SIGNIFICANCE A. Review of relevant literature Epstein-Barr-virus (EBV) is a member of the gamma herpesvirus family that establishes a persistent infection in approximately 90% of the world’s population. In immunocompromised individuals, EBV infection can contribute to cancer development like nasopharyngeal carcinoma, Burkitt lymphoma and Hodgkin’s disease. The latent membrane protein 1 (LMP1) is expressed

Primary Article Assignment Microbiology ICP#1 (Viruses) Name: Katie Slivko ____________________________________________________________________ 1) Anatomy of Paper a) 19 authors (Rodrigo Delvecchio, Luiza M. Higga, Ana Luiza Valadao, Fabio L. Monteiro, Paula Pezzuto, and Patricia P. Garcez) ect. b) They all worked at the Institute of Biology at the Federal University of Rio de Janerio. In addition, it seem that they all had experience with infectious disease. Most of the authors worked in genetics

We yoked proton MR spectroscopy to a 10-week, placebo-controlled, double-blind, randomized controlled trial (RCT) to study whether patients with DD have abnormal levels of brain metabolites and whether those abnormal levels are normalized towards healthy values following successful treatment with antidepressant medication. Our baseline findings showed that patients relative to healthy controls had abnormally high levels of metabolites in several subcortical gray as well as in WM regions of the brain