ell lines including Breast and ovarian carcinoma to overcome the adverse side effects[13]. The results showed that targeting the LHRH receptors by using the LHRH peptide based delivery system substantially enhanced the efficacy of the chemotherapy. The LHRH targeted delivery system also did not show in vivo pituitary toxicity in the human ovarian carcinoma xenografts.
Herein, we report the PEG-LHRH peptide conjugated mTS-mPAE NPs for the targeted delivery of mTOR siRNA to the lung tumor cells, utilizing bioreducible cationic polymer mPAE based NPs as the delivery carrier. Towards this aim, mTS-mPAE NPs was synthesized using the nanoprecipitation method to encapsulate the mTOR siRNA and form mTS-mPAE NPS. The mTS-mPAE NPs was then conjugated with PEG and PEG-LHRH to form non-targeted(NT-NPs) and targeted (T-NPs) gene delivery system for the treatment of lung cancer. The NT-NPs and the T-NPs of uniform size, zeta potential were produced. The PEG and PEG-LHRH was conjugated on the NP surface by covalent conjugated.
Serum Stability –
Serum protection
The stability of polymeric nanoparticles in serum is critical to their use in drug delivery where dilution after intravenous injection often results in nanoparticle disassembly and drug unloading;[14]
The circulation time of nanoparticles in vivo is influenced by many factors, including size, size distribution, and surface charge which in turn influence the degree of interaction with serum proteins. Protein adsorption is a key
1. A genetic mutation gene is a gene that is passed from family member to family member; There are two types of these genes and one is called BRACA
Cancer is started when the DNA in a cell becomes damaged. The mutated cells caused by the damaged DNA rapidly reproduce which can cause tumors to form. There are two types of tumors, benign tumors and malignant tumors. A benign tumor is non-invasive, and an malignant tumor is invasive. Breast cancer generally will form in the lobules or milk ducts. Lobular carcinoma in situ, also called LCIS, is non-invasive. That means the it forms and stays in the lobules. Lobular carcinoma is invasive. That means that it develops in the lobules and breaks through and has a potential to spread to other parts of the body. Ductal carcinoma in situ is non-invasive. It forms and stays in the milk ducts. Ductal carcinoma is invasive and is when ductal carcinoma
Asma mentioned a metaphor used by her doctor to describe her sexual condition after treatment who said ‘your ovaries are expired like an old lady’. At this point of the interview Asma cried because she felt different and experienced symptoms not associated with her age group.
without living a healthy lifestyle. Making sure to take care of ones body is an important factor in the prevention of breast cancer.
The use of hormone therapy can be of relief of the awful menopausal symptoms a woman may experience, but this does not come without risks. A combination therapy of estrogen and progestin (a form of progesterone made in the lab) is what is commonly used. The National Institutes of Health’s Women’s Health Initiative Study found that women who are taking
For this assignment I decided to critique a website from the topic breast cancer. I started my search by typing breast cancer in the google engine. I then clicked on page eight until I found a website with a .com. I clicked on the article about breast cancer, then went to website the article was provided by. Critiquing a website can be difficult do to constant evolving of technology. As a result, the accuracy of a website need to be updated continuously. To ensure that your website is . I evaluated the EMedicineHealth website using the Evaluating Internet Research Sources from Robert Harris (Harris, 2010). This consists of an acronym for evaluation CARS (credibility, accuracy, reasonableness, and support). It was with this tool
In our world full of diseases, illnesses, and infections, Cancer is such a shared disease that it is no disbelief that numerous families have at slightest a few members who have cancer. Cancer a syndrome people may perhaps partake in their genetic factor. Cancer is roughly capable of establishing just about anywhere in the body. It is the abnormal cells in one’s body which develop uncontrolablly that cause cancer. Cancer is the second leading cause of death in the U.S. Cancer is something that progresses in the body when the irregular cells block out the standard cells and preserves them from undertaking their job accurately. Customary cells in our
Breast cancer is a serious condition and takes many people 's lives each and every year. It accounts for at least 18.2% of cancer deaths worldwide.1 In society today, women are more focused on what appeals to men, rather than worrying about their own health. “If only women paid as much attention to their breast as men do” is promoted by National Breast Cancer Foundation. 2 The message that I took from this PSA is the notion that women do not pay enough attention to their bodies from a health standpoint. Men are seen paying more attention to our breast than we do. Being educated on pre-screening techniques, signs, & overall education about breast cancer could help increase awareness and decrease incidence rates3. Women need to stop obsessing about self-image and start focusing more on their overall health. Breast cancer is a serious invasive cancer and if we paid more attention to it then the better prepared we will be in the future. This lead me to find two studies related to Breast cancer awareness. The two studies look at different groups and measure and evaluate their knowledge of risks & symptoms, pre-screening techniques.
Breast cancer is the second most common cancer in women worldwide. The most common type of breast cancer is ductal carcinoma, which arises in cells that lines breast duct. Many imaging techniques are used for the screening and diagnosis, but typically patients are diagnosed at advanced stage only, and the prognosis is associated with early detection. At present serum and protein biomarkers improving early detection of breast cancer, these make better treatment options with a better response. MicroRNAs and CA 15-3 most widely used serum biomarker in breast cancer. Amplification of chromosomal regions encoding oncogenic miRNAs is consequently silencing or inhibits tumor suppressor genes. The standard treatment options for breast
When people hear breast cancer, they usually think of women first. Unfortunately, breast cancer can affect men as well, although at a slight lower rate. However, it is the most common type of cancer among women. For women, the breast becomes an important organ during childbirth, primarily for breast-feeding. Of course, every organ is important as they play their own vital roles; however, the breast takes on a number of significant roles to keep the body properly functioning. Unfortunately, as with most parts of the body, the breast is susceptible to disease, the most important and deadly of which is cancer. Learning about breast cancer is incredibly important because plenty of men and women may not have knowledge about the symptoms, and as the war on cancer wages on, we are losing more and more victims. Breast cancer cannot only affect you, but your friends, family, and loved ones as well. Hopefully, talking about the anatomy and functions of the breast, the problems and symptoms of breast cancer, and how to prevent it will help expand awareness of breast cancer and learn exactly what it does to the human body.
Breast cancer is the most common malignancy among women and has the highest fatality rate of all cancers affecting this sex. It is the leading cause of death among women aged 35-54. In 1999 an estimated 175,000 women were diagnosed with breast cancer. That is one woman every three minutes. At the same time 43,000 will die, at the rate of one every two minutes. The incidence of men diagnosed with breast cancer is rare, however it does occur. Approximately 1,300 men a year are diagnosed, and 400 die annually due to the disease. A total of 75% of all breast cancers occur in women with no known risk factors. 80% of breast cancers occur in women aged 50 and up. The mortality rate would decrease if
Breast cancer cells have receptors on their surface and in their cytoplasm and nucleus. Chemical messengers such as hormones bind to receptors, and this causes changes in the cell. Breast cancer cells may or may not have
The older adult I interviewed for this assignment was my mother, Marie Baldwin. She is 65 years old and is in good health. She works out consistently, eats a well balanced diet, and goes to the doctor regularly. She has high cholesterol, which is largely due to genetics. She does not take medication for it; rather, she controls it through her diet. My mom had breast cancer six years ago and underwent a mastectomy and chemotherapy. The cancer is in now in remission and she made a full recovery. She does have chemotherapy induced peripheral neuropathy in her hands, legs, and feet, so she experiences pain, tingling, and numbness, which she manages with pain medication. Other than breast cancer, she has not had any other major health concerns. She has been retired for five years and lives a fairly relaxed lifestyle. She wears glasses for reading and has lost some of her hearing. My mom has a herniated disc in her lower back, and does daily exercises she learned from doing physical therapy to keep it from flaring up. She does cardio and weight training a few days a week and stretches for her back.
With a change in focus, recent advances in this field have led researchers to develop targeted anticancer agents that have the potential to reduce the side effects associated with classical chemotherapeutics, which include nephrotoxicity, neurotoxicity, leukopenia, thrombocytopenia, nausea, vomiting, and hair loss.5,6 A promising advancement in chemotherapeutics is the development of therapy that targets various biomolecules that are associated with cancer. Known as targeted therapy, this offers significant potential for increasing selectivity by synthesizing compounds that are directed towards cell signaling pathways known as important for cancer cell immortalization.7 Moreover, targeted therapy shows promise with synthesized drugs directed for cancer biomarkers because it will increase selectivity to damage cancer cells instead of healthy cells.8 The early generations of chemotherapeutics largely focused on creating more potent metal complexes, analogous to the structure and function of cisplatin.4 However, with targeted therapy as a promising advancement, the next generation of chemotherapeutics instead focuses on selectivity in the preparation of transition metal complexes that are directed toward specific biomolecules that are known to advance cancer cell
Targeted alpha therapy (TAT) is a promising method of the targeted radio- immunotherapy for the treatment of hematologic malignancies and extended to treat various solid cancers. Alpha-immuno-conjugate (AIC) is the diagnostic radiopharmaceutical compound used in clinical trials of TAT. Two essential elements of AIC must be included: a targeting antigen as a carrier that tends to attach to the molecules on the surface of a specific tumor cells; and an Alpha emitter that undergoes Alpha decay to damage the DNA of the targeted cell [1]. With the use of such a targeted high linear energy transfer (LET) radiation therapy, highly targeted treatment to microscopic tumor cells with AIC becomes an emerging option for local and systemic cancer