Nowadays, there is an increasing demand on multifunctional excipients that replaces the need and use of multiple excipients. There are two ways that can fulfill this requirement, first, the development of new excipients with new chemical entity that has good properties including stability, flowability, compressibility, etc… and is compatible with other excipients in the formulation and with the Active Pharmaceutical Ingredient (API). The second way is to make new grades of exisiting excipient, or to modify it in a way that meets the needs of development. Excipient modifications can be categorized into chemical and physical modifications. The chemical modification deals with chemical reaction that add,…show more content… Table 1 shows the general advantages and disadvantages of coprocessing. As shown in the table, if an excipient has certain limitation such as poor flowability and compressibility, coprocessing could be the solution to overcome this problem. On the other hand, coprocessed excipients ratio is fixed and can’t be changed. Sometimes this ratio may be incompatible with the API or with the dose .
In general, coprocessing is carried out for one plastic and one brittle-deforming excipient in order to minimize the elastic energy stored during compression and to decrease capping or lamination of the tablet, in addition, this combination is reflected positively on the compressibility of the powder. Coprocessed excipient use in direct compression tablet manufacturing process combines the advantages of wet granulation with the fast processing of direct compression. As mentioned above, the ratio of initial excipients included in the coprocessed excipient is fixed, the particles of the excipient with the lower percentage can be processed on the surface or in the core of the other excipient. Excipients must be homogenized and then coprocessed