An Anti ‐ Inflammatory Effects

1312 WordsFeb 27, 20176 Pages
Cranberry contains high levels of nutrients and bioactive molecules that have health‐promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti‐inflammatory effects. The human monocytic cell line THP‐1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor α (TNF α) expression was decreased in the CE‐treated cells, indicative of an anti‐inflammatory effect. Gene expression microarrays identified several immune‐related genes that were responsive to CEs including interferon‐induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and…show more content…
2004). Cranberries, in powder, extract or juice, have been reported to be beneficial for helping prevent urinary tract infections (Wang et al. 2012; Blumberg et al. 2013; Foxman et al. 2015), oxidative stress and cardiometabolic risk factors such as reducing C‐reactive protein and lowering blood pressure (Basu et al. 2011; Dohadwala et al. 2011; Novotny et al. 2015). As cranberry is a natural food product and not a drug, the effect seen is often mild but that is consistent with the recommendation for a food with health components that is consumed as part of a healthy balanced lifestyle. In vitro evidence has shown the antioxidant potential of cranberry phenolic compounds including protection of human microvascular endothelial cells against ROS, and HepG2 cells from inflammatory insults and reduced glycation (Caton et al. 2010; Crozier et al. 2010; Liu et al. 2011; Watson et al. 2014; Martín et al. 2015). A recent publication also showed the bioavailability and bioactivity of cranberry phenolics and metabolites from consuming cranberry juice beverage (McKay et al. 2015). The protective effect of these compounds may be related to their function in sequestering ROS and/or maintaining the cell components in their correct redox state, but
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