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Benefits Of Lamotrigine

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Lamotrigine is an anticonvulsant drug that has been approved by the FDA; it is used for the treatment of epilepsies and for the maintenance treatment of bipolar disorder. Unlike other conventional antidepressants, lamotrigine can be used for treatment of major depression without inducing mania (17, 59). Lamotrigine is less effective in the treatment of acute mania or acute depression, however it is found to be effective in delaying the onset of mania (60). Several studies has shown that lamotrigine in combination with conventional -26- antidepressants such as SSRI’S, have greater efficacy than that of SSRI’S monotherapy as well as faster onset of action (62). In addition, two randomized control studies in bipolar patients showed that lamotrigine…show more content…
The use of lamotrigine is associated with several adverse effects such as headaches, nausea, fatigue, ataxia, fever, aseptic meningitis, diplopia, blurred vision, insomnia, nightmares, xerostomia, abdominal pain, painful mouth sores , muscle pain, yellowing of the skin and eyes, restlessness, weight loss, suicidal ideation and mood alternation (22,65,68). However, the most serious adverse effect associated with lamotrigine is a life threating skin rash including Steven-Johnson syndrome and toxic epidermal necrolysis (17,22,66,67). Lamotrigine is categorized as class C drug according to the pregnancy safety category (42)With overall risk for major congenital malformation estimated to be 2-3% based on registry based studies of pregnant women with epilepsy (30,44,69). Data obtained from the international lamotrigine pregnancy registry have shown that combination of lamotrigine with valproate has much higher rates for congenital malformations (10.7%) compared with lamotrigine monotherapy
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