Bone Marrow Derived Mesenchymal Stem Cells Essay

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Bone marrow-derived Mesenchymal Stem Cells (BMSCs) are fibroblast-like cells. They are considered self-renewing, expandable, clonal precursors of nonhematopoietic tissues. BMSCs are present as a rare population of cells in bone marrow, representing 0.001–0.01%(93). They are characterized by combinations of cell surface markers and their ability to differentiate into bone, fat and cartilage, in-vitro(94). BMSCs can be safely expanded in vitro without being susceptible to malignant transformation, thus rendering these cells suitable for cell therapy approaches. These cells possess the ability to engraft at the site of injury and promote tissue regeneration and wound healing through synergistic downregulation of proinflammatory cytokines and…show more content…
These data suggested that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds. Falanga et al.,(98) showed the effect of a single autologous BMSCs on the rate of healing of human acute (skin cancer surgery) and chronic (long standing-non healing) skin wound. BMSCs were grown in vitro and characterized using flow cytometry and immunostaining. They mixed the cells with fibrinogen and thrombin to form a polymerized gel that was applied to the wound topically using fibrin polymer spray system with double-barrelled syringe. They found that in vitro BMSCs expressed CD29, CD105 and CD 44 and were negative for CD34, CD45. They detected a notable decrease in chronic wound size and complete closure of the wound in 6 month. Also, they tracked BMSCs in full-thickness wound in diabetic mice using fluorescence dye and examined the specimen microscopically with haematoxylin and eosin staining. They found that the applied cells did not persist in great numbers in healed wounds. However, their effect in accelerating the healing was remarkable. Kotenko et al.,(99) examined the effect of BMSCs on healing of wound ulcer in rat induced by radiation. They found that BMSCs stimulated accelerated healing and recovery of

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