Causes And Consequences Of Data Analysis

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The primary outcome was the time to incision; duration from clinical decision to operate to the time of incision. Secondary outcomes included ΔINR, rate of INR correction per hour, INR rebound, intra/post-operative bleeding, reoperation for bleeding, thromboembolic complications, 30-day mortality, number and type of blood products used, duration of hospital and intensive care unit stay.
Normally distributed data were reported as mean ± standard deviation. Nonparametric data were reported as median (interquartile range). Categorical variables were reported as counts and percentages. Chi square was used to compare categorical variables between the three groups. Analysis of variance (ANOVA) and each pair student test were used to compare the …show more content…

The most common operation performed was an exploratory laparotomy with bowel resection in 40% of the patients. Out of these bowel resections, 47% were small bowel, 39% were large bowel, and 15% had both small and large bowel resections. Out of all surgeries performed, 84% were open, 15% were laparoscopic and 1% were laparoscopic converted to open.
The median (IQR) dose of PCC administered was similar in the PCC/FFP and the PCC alone groups {2076 International Units (1343-3279) vs 2988 International Units (2193-4500), p=0.09}. The median (IQR) preoperative FFP units administered was greater in the FFP group compared to the PCC+FFP group {3 units (2-4) vs 2 units (2-3); p=0.03}. Preoperative PRBC transfusion requirements in the PCC/FFP group were higher compared to the FFP group and the PCC group {1.1±0.3 vs 0.4±0.2 vs 0.1±0.4; p=0.0006}; otherwise, there was no significant difference between the groups in total PRBC (p=0.11), intraoperative PRBC (p=0.20), postoperative PRBC (p=0.57), total platelets (p=0.29), preoperative platelets (p=0.45), intraoperative platelets (p=0.43) and postoperative platelets (p=0.46) transfusion requirements throughout the hospital stay. Figure 2 demonstrates the differences in time to incision for each reversal agent. There was a significant reduction in the mean (±SD) time to incision in the PCC group compared to the FFP group {6.0 (3.6) vs 8.8 (5.0); p=0.01}.

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