Chlortetracycline

Malaria has been a major life-threatening disease for thousands of years, and continues to threaten millions of lives around the world. It infects approximately 219 million people each year, mostly poor women and children. What is striking about malaria is the fact that it has the worse effect on those with the least ability to fight the disease. The Republic of Cuba believes that malaria prevention, treatment, and research efforts must be accelerated to eliminate the burden of this disease across Africa, Asia, the Americas, and any country or territory at risk of malaria transmissions.

Brian, G, Y., Greenwood, D, A., Fidock, Dennis, E, K., Stefan, H, I. Kappe, P., Alonso, L., Frank, H and Collins, P (2008) “Malaria progress and prospects for eradication.” Journal Clinical Investiment. 118: 1266-1276.

Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases

Background - Malaria is a water borne disease. It is spread by a parasite-carrying mosquito. It kills many people and reduces a country 's capacity to develop. There are different strategies to combat malaria. Around half the population is at risk of malaria and this disease is active in 106 counties across Africa, Asian and the Americas (see source 3). the global annual mortality from malaria is between 1.5 - 3 million deaths, or between 4000 and 8000 each day. Developing countries are most vulnerable to Malaria and as shown on source 2 Malaria has been spread across many various other countries including in Europe, but these countries have eradicated Malaria.

about 207 million cases of malaria and 80% of cases of malaria in the world are in Africa. There

Tetracycline, synthesized from chlortetracycline, a compound produced by a Streptomyces. It works by binding to the bacterial ribosome and interfering with protein synthesis and is effective against a wide range of Gram positive and negative bacteria, including the Mycoplasma and the bacteria responsible for Rocky Mountain Spotted Fever and nongonococcal urinary tract infections. (DrugBank)

Malaria is a disease that affects nearly 600 million people and causes more than a million deaths a year, the most coming from children under five. This disease is regularly found in more than 100 countries around the world and affects 40% of the world’s population. It is most commonly transmitted by an infected Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. Some of the symptoms that are affiliated with this strand of malaria are the destruction of red blood cells along with complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennium and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, “a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.”

First of all, an increase in the use of insecticide-treated bed nets has reduced malaria. Approximately 60% of children under age five and 55% of pregnant women now sleep under mosquito nets, up from only 9 per cent in 2001. Nearly 3 million nets were retreated with insecticide in 2005. In addition, treatments for malaria are becoming more accessible. The Malawi Ministry of Health’s National Malaria Control Program has been able to scale up the distribution of artemisinin-based combination therapies and intermittent preventive treatment for pregnant women. Because of all the prevention efforts and treatments, the incidence of Malaria has decreased over time. For example, Malaria incidence in 2015 was 386 per 1000 population representing a 20% reduction from 484 per 1000 in 2010. Also, the number of deaths due to Malaria has lessened from 5.6% to 3.4% in 2004 and 2009. Eventually, malaria will no longer one of the biggest killers in

After 48 hours, the experimenter was able to obtain the Petri dish in order to observe what had taken place, within the nutrient agar plate, of the span of this period of time. The experimenter was able to establish that any clear areas surrounding the filter-paper disks were the zones of inhibition and they indicated that the antibiotic was able to inhibit the bacterial growth, and any cloudy areas of the agar demonstrated that bacterial growth was still able to take place within the given conditions. Thus, the larger the zone of inhibition, the more bacteria was inhibited within this specific environment. Quadrant 1 contained an Erythromycin filter-paper disk, which was able to inhibit the growth of Bacteria D. The Erythromycin filter-paper

Malaria has been a huge problem among many developing nations over the past century. The amount of people in the entire world that die from malaria each year is between 700,000 and 2.7 million. 75% of these deaths are African children (Med. Letter on CDC & FDA, 2001). 90% of the malaria cases in the world are located in Sub-Saharan Africa. Once again, the majority of these deaths are of children (Randerson, 2002). The numbers speak for themselves. Malaria is a huge problem and needs to be dealt with immediately.

Minocycline is one of many medications that falls under a broad category of anti-infectives known as Tetracycline’s. Tetracycline’s “inhibit protein synthesis at the level of the 30S bacterial ribosome” (Vallerand, 1185) or in

*Tigecycline (TIG), a derivative of minocycline, overcomes most of the known tetracycline resistance mechanisms. The discovery of TIG represented significant progress, because it is active against a wide spectrum of Gram negative and Gram positive pathogens, especially multidrug-resistant strains. Tigecycline, similar to tetracycline shows antibiotic properties, but is not affected by tetracycline resistance mediated by efflux or ribosomal protection proteins. This allows TIG to evade the common ribosomal protection mechanisms associated with resistance to

Directions: Read the following background information on malaria interventions in Africa which has been excerpted from (Cataldi et al. 2009). Then, answer the questions at the end of the document prior to our in-class discussion.

About 3.3 billion people, that is about half of the world’s population are at risk of contracting malaria (figure 1). Every year there are 250 million cases of malaria, and nearly 1 million deaths. That amounts to 2,732 deaths per day. Out of those million people that die every year, 800,000 of them are African children under the age of 5. To control malaria three actions need to be taken: insecticides need to be used to decrease the vector population, people have to be educated as to how to prevent the vector from reproducing, and anti-malarial drugs need to be distributed. To understand the vector and what the vector is, scientists had to first discover what the parasite was and how it worked. It was not until the year 1880 that French Physician Charles Laveran discovered that Malaria was caused by a protozoan in the genus Plasmodium (Malaria, 2013)

Arthropod transmitted diseases are the cause of high mortality rate in developing countries. Malaria is one of the most dangerous arthropod diseases that concern mostly children under five years old and pregnant women. Malaria is a human disease caused by a parasite called plasmodium falciparum transmitted by infected anopheles mosquitos. Anopheles mosquitos’ mouthpart is called proboscis that sting and sucks on human. The sting of anopheles mosquitos can last up to two minutes. It injects an anesthetic and its saliva in the skin and proceeds to suck the blood of its victim leaving sometimes a small allergy reaction on the skin. People suffering from malaria present the following symptoms: Fever, headaches, cold, stomachache, anemia and so much more. Malaria is a severe disease that contributes in lower levels of educational attainment and higher rates of poverty later in life. In India only, “The treatment for malaria cost per episode in Government Hospitals excluding medication & consultation fees was between 2.43 US$ (Rs 150/-) and 3.25 US$ (Rs 200/-) while in private clinics this figure ranges from 8.93-12.17 US$ (Rs 550 - Rs750/-) which was around 4-5 times higher than in the Government hospitals. The total average of direct cost per malaria episode in Rohtak region was 11.38 US$ (Rs 701/-) while this was 13.31 US$ (Rs 820/-) in Mewat region leading to an enormous cost to households living below poverty line (BPL).” (Estimating the economic burden of malaria and