Colorectal Cancer Increasing Risk Factors

There are many risk factors for stomach cancer. Gender is a minor risk factor because men are more likely to get stomach cancer than women are. Age is a risk factor as well because most people are over the age of 65 when they are diagnosed with stomach cancer. Ethnicity is a big risk factor because the rate cancer is higher in Hispanics and African-Americans rather than non-Hispanic white. Tobacco use is a risk factor for stomach cancer along with most of every other type of cancer. Smoking doubles the risk for someone to get cancer. It has been proven that people with Type A Blood are more likely to get stomach cancer as well. Some other risk factors are things like bacteria infection, diet, earlier stomach surgery, stomach polyps, and oddly enough, some occupations in coal, metal, and rubber industries are even risk factors of stomach cancer.

The Ministry of Health has contributed almost $40 million dollars, over the past four years, towards the development and implementation of the National Bowel Screening Programme (Ministry of Health [MOH], 2016a). The aim of this is to develop a programme to regularly screen people who are considered a ‘high risk’ for developing colorectal cancer. People considered to be at a high risk for developing colorectal cancer are those of advancing age (60+), previous colonic polyps, a diabetes diagnosis, and those who have a previous family history of colorectal cancer (Brenner, Zwink, Ludwig & Hoffmeister, 2017, p.95; Dallas, 2017; Engelke, 2016).

Colorectal cancer mainly starts at colon or the rectum. They are common in most of the way like features, but they have different treatment. What is the different between colon cancer and rectum cancer? Colon cancer happens first four to five feet of the large intestine and rectal cancer happens in the last few inches of the large intestine where it is connected to anus.

Cancer is the leading cause of death among Asians Americans, and rates vary with age, acculturation and location. The stated differences may represent the influence of environment, such as diet and health habits, and therefore may be modifiable. When it comes to liver and stomach cancer, Asian Americans are tree times more likely to develop liver cancer than non-Hispanic whites and twice as likely to develop liver cancer. In the Chinese, liver cancer is associated with Hepatitis B (precursor to liver disease and cancer) and in whites, liver cancer is primarily associated with alcohol. For colon cancer, it is suggested that diet is related, so is other environmental risk factors. Breast cancer is the most commonly diagnosed cancer among Chinese

Imagine having an almost 100% chance of developing colon cancer. That is what people are told with Familial Adenomatous Polyposis (FAP) if they do not have their over 100 polyps, or growths, removed. FAP is a genetic disorder where normal cells that line your large intestine can grow into cancerous tumors. These tumors must be removed before they become cancerous. This disorder is passed down from parents on the APC gene which is on your fifth chromosome. If the APC gene is mutated you are more likely to develop these growths which lead to cancer in your lifetime. This disorder has an autosomal dominant inheritance pattern, which means if either parent has just one dominant mutated APC gene you have a 50% chance of inheriting it. Symptoms of FAP do not just include the growths in your colon. They can also include skin changes, osteomas or bone growths, and extra or missing teeth.

The signs and symptoms of colon cancer include blood in the stool, weight loss, change in movements in the bowel and fatigue. Most colon cancers are adenocarcinomas because they begin in the cells responsible for making and releasing mucus and other fluids. Colon cancer usually begins as a type of growth known as a polyp which forms in colon or rectum’s inner wall. Some polyps may develop to become cancer after some time. Diagnosing and removing polyps is used to prevent cancer. In the United Kingdom, colon cancer is 3rd most common type of cancer for women and men. However, deaths associated with the cancer have been decreasing after the use of colonoscopies as well as fecal occult blood tests which are used to check for the presence of blood in people’s

Maori aged 60-69 years were 1.5 times more likely to have an adenoma detected than Europeans of the same age (Ministry of Health, 2015). Maori were almost 1.5 times more likely to have an advanced adenoma detected than Europeans (Ministry of Health, 2015). Asians were over 1.5 times less likely to have an advanced adenoma detected than Europeans (Ministry of Health, 2015). There was a recommendation that Asians were less likely and Maori were more likely than Europeans to have neoplasia detected, but this was not statistically significant (Ministry of Health, 2015). Asians were less likely than Europeans to have either advanced adenoma or colorectal cancer detected (Ministry of Health, 2015). The Positive Predictive Values for adenoma and advanced adenoma was lower for females than males (Ministry of Health, 2015). The PPV for adenoma was about 1.5 times less for Asians

Squamous cell carcinomas cancer is the most common colon cancer in the United States. It is located within the anal canal and around its walls. This sparks my interest because it is quite odd to me that cancer could occur in the anal canal or outside of it. It really shows how cancer can literally occur anywhere in the body. Even Though it is located in the anal canal, the cause of colorectal cancer is usually due to many other reasons that has nothing to do with the colon itself. These causes are the amount of exercise a person have, any smoking or drinking, even if the person is overweight, or attaining HPV. There are also many causes that can not be changed by your lifestyle, for example if you have the genes to have colorectal cancer or

Lynch syndrome, also known as Hereditary Nonpolyposis Colorectal Carcinoma (HNPCC), was characterized in 1966 by Henry T. Lynch. His research in the 1960’s was prompted by a single patient’s response. According to (Lynch & Lynch, 2004, p. 182), “…the patient’s response was that he knew that he, like “everyone” in his family, was going to die of cancer, and that it would likely be cancer of the colon, although he realized that many other cancers had also affected the family” (p. 182). Years of research involving this patient’s family led to a common connection. Family N showed a well-defined autosomal dominant mode of genetic transmission of carcinoma of the colon with early age of cancer onset, multiple primaries, and with the integral association of carcinoma of the endometrium and ovary (Lynch & Lynch, 2004, p. 182-183). Therefore, it was found that gene mutations put a person at high risk for CRC and endometrial cancer at a much younger age. Since then, Lynch

Colorectal cancer is the third most common cancer among men and women in the United States, and mutations in the MUTYH gene significantly increase the risk of developing polyps that may evolve into cancer.1,2 Biallelic mutations in the MUTYH gene can lead to MYH-Associated Polyposis (MAP), which causes the growth of dozens to hundreds of polyps, furthering increasing the risk for colon cancer.2 Meanwhile, recent studies have shown that both biallelic and monoallelic mutations can contribute to bladder, ovarian, gastric, hepatobiliary, endometrial, and breast cancer.3 The MUTYH gene itself codes for the MYH glycosylase enzyme, which repairs mistakes in DNA caused by reactive oxygen species.3,4 Also a sign of oxidative stress, the oxidation product, 8-oxo-7,8-dihydro-2-deoxyguanosine (OG), mimics thymine, eventually matching with adenine and resulting in a complete loss of the cytosine-guanine pair.4 MUTYH removes the undamaged A base from the mismatched pair, aiding in the correction of such damage.4 However, when MUTYH is mutated, there is an increase in G to T mutations, which can eventually affect the tumor suppressor genes APC and K-ras and lead to tumor formation.4 The MUTYH variants Y165C and G382D are the most common mutations seen in individuals with MAP, and for this reason are of great interest in research working towards reducing the risk of colorectal cancer.2,4 In recent years, the CRISPR/Cas system for gene editing has become the preferred method for

(WENY) - Every year nearly 50,000 people die of colon cancer in the United States and is the third leading cause of cancer related deaths.

Familial adenomatous polyposis (FAP) is an autosomal dominant polyposis syndrome classically characterized by mutation in the APC gene on the long arm of chromosome 5. Patients are diagnosed with FAP had hundreds of thousands of adenomatous polyps in the large intestine (Poovorawan et al., 2012). Truncating germline mutation in the APC gene are responsible for 70-90% of FAP cases (Russo et al., 2014). FAP is dominantly inherited and is close to 100% penetrant. Therefore, it is essential to have knowledge of the disease in advance in order to have sufficient medical preparation.

Description: I had the chance to work on multiple manuscripts pertaining to colorectal cancer in African Americans and Caucasians. My contribution included compiling the results from each experiment and inputting them into the corresponding manuscript, creation of all necessary tables and figures, as well as proofreading all sections to correct any mistakes.

the United States, colorectal cancer is the third most common cancer among both men and women separately, and the second most common cancer overall.

Colorectal cancer is one of the global leading diseases and it is the third most common causes of death in both men and women in America. Approximately 1 in 12 Australians will develop colorectal cancer in their lifetime, and according to Bowel Cancer Australia, individuals are at risk if they are aged 50 years and over, have had an inflammatory colorectal disease or significant family history of colorectal cancer polyps.