# Comparative Evaluation Between Mathematical Models For Drug Release Of Curcumin Loaded Multifunctional Albumin Nanoparticles

917 WordsMay 5, 20174 Pages
COMPARATIVE EVALUATION BETWEEN MATHEMATICAL MODELS FOR DRUG RELEASE OF CURCUMIN LOADED MULTIFUNCTIONAL ALBUMIN NANOPARTICLES Abstract: Curcumin loaded albumin nanoparticles were employed for intra-tumoral chemotherapy for treatment of solid tumors1. Drug release study for Curcumin was monitored in-vitro using dialysis1. The drug release data was fitted into 5 mathematical models such as zero order, first order, Hixen-Crowell, Higuchi release and Korsmeyes-Peppas release kinetics model. R2 coefficient was compared and was concluded that Higuchi release kinetics model is best suited for the drug release kinetics for Curcumin. Introduction and Significance: Nanoparticle formulations have found extensive applications as drug delivery…show more content…
Analysis: Drug release data for curcumin was fitted into 5 mathematical models and studied to determine the best mathematical model. The model chosen were: i. Zero Order Kinetics The zero-order kinetics depends upon the initial concentration of the drug loaded on the nanoparticles and refers to constant release of drug5,6. Zero order kinetics is represented as: Qt=Qo+k*t Qt = amount of drug dissolved in time t, Qo=initial amount of drug, k=zero order kinetics constant ii. First Order Kinetics The release of the drug which followed first order kinetics can be expressed by the equation7: log C = log C0-Kt / 2.303 Co is the initial concentration of drug, k is the first order rate constant, and t is the time iii. Hixon-Crowell Release Kinetics Hixson and Crowell derived the equation: Q01/3-Qt1/3 = κ*t where Q0 is the initial amount of drug, Qt is the remaining amount of drug at time t and κ (kappa) constant incorporates surface volume relation. The equation describes the release from systems where there is a change in surface area and diameter of particles or tablets9. iv. Higuchi Release Kinetics Higuchi drug release kinetics model was proposed Higuchi in 1961 based on a matrix system8. The matrix model is based on initial drug concentration in the, instantaneous drug