The Evidence Based Pharmacology of Asthma Management The number of chronic diseases and individuals suffering continues to rise with the ever-growing population. One of these chronic diseases which is very common and affects all age groups as well as ethnic groups is asthma. There are current estimates of the number of individuals suffering from asthma internationally to be 300 million and the chance for the number to reach 400 million by the year 2025 (Alhassan, Hattab, Bajwa, Bihler & Singh, 2016). The condition is responsible for roughly 250,000 international deaths yearly with the prevalence of the disease increasing and despite a decline in deaths within the last decade (Alhassan et al., 2016). Asthma presents more commonly in children …show more content…
Roughly half of all cases of asthma are genetically linked, while the other half of cases are more commonly related to the exposure of environmental factors (Martinez & Vercelli, 2013). The current genetic studies for asthma are limited and require further research to identify the variations between familial tendencies and environment exposures which trigger asthma in individual. However, with cloning practices five genes related to the presence of asthma in individuals have been identified. These genes consist of ADAM33, DPP10, PHF11, SPINK5 and GRPA (World Health Organization (WHO), n.d.). In addition to the identification of underlying genetic links to asthma, the term atopy is most commonly used to explain related genetics and environment susceptibilities for individuals suffering from asthma. Individuals who suffer from asthma are often genetically predisposed to produce IgE in response to environment allergen exposures contributing to the inflammatory response and clinical symptoms of asthma (Arshad, Karmaus, Zhang, & Holloway, 2017). Individuals with family history, an increased level of IgE and positive skin allergies are also predisposed to the risk of asthma (Alhassan et al., 2016). While progress has been made to identify genetic tendencies, further research is required to understand the link …show more content…
The etiology of asthma and pathophysiology has been studied extensively throughout the decades. The condition is one of the most common lung diseases worldwide and is responsible for deaths with a higher prevalence among black Americans and Hispanics (Anise & Hasnain-Wynia, 2016). There is a clear definition of asthma and a consensus of the underlying processes which contributes to the clinical symptoms present in individuals experiencing an acute exacerbation. Asthma is clearly defined as a heterogeneous condition affecting individuals along the life span which is triggered by allergens, non-allergens and viral or bacterial sources (Martinez & Vercelli, 2013). Furthermore, the condition is described as an inflammatory disease of the airway that results in an immune mediated response creating symptoms that may include, bronchoconstriction, wheezing, coughing, increased mucous production and airflow obstruction (Alhassan, 2016 ; Barnes, 2016). The inflammatory response which occurs involves either helper T cells or lymphoid cells depending on the initial trigger and with recurring episodes affect the respiratory system, creating changes structurally to the airway (Barnes, 2016). These changes may consist of thickening of the airway cells, the increased risk of creating mucous plugs within the airway and fibrosis (Barnes,
Asthma is a chronic inflammatory disease of the airway that impacts a person’s and their family’s quality of life. In people with asthma, their airway becomes constricted with swelling and excessive mucous. This constriction or narrowing of the airway makes it difficult for the person with asthma to breath (Massachusetts Department of Public Health, 2009). If asthma is left uncontrolled, it leads to further wheezing, coughing, shortness of breath, tiredness, and stress. (Massachusetts Department of Public Health, 2009).
To better understand the impact of asthma, a brief overview of the causes (aetiology) and disease progression (pathophysiology) must be shown. As common as asthma is, not much is known about its aetiology, according to findings presented by Subbaroa, Mandhane and Sears (2009, pg. 181-187) in a review from the Canadian
Asthma is a chronic inflammatory disorder of the bronchial mucosa and hyperreactive bronchial tubes. Its etiology has been linked to both genetic and environmental factors. Several genes, including those that influence the production of proteins and cells involved in the immune response (such as interleukins, eosinophils, mast cells) have been linked with asthma. A decreased number of T-regulatory cells is also associated with asthma. Environmental factors linked with asthma include exposure to allergens, urban residence, and smoking (or exposure to secondary smoke). Recurrent respiratory tract viral infections may also contribute to the development of asthma. Decreased exposure to certain infectious organisms during early childhood, and the consequent underdevelopment of the immune response, can also lead to the development of asthma--this is known as the hygiene hypothesis (McCance & Huether, 2014, p. 1263-4).
Asthma is a respiratory disease that many people deal with every single day. “According to World Health Organization, approximately 180,000 people die from asthma each year.” (Jardins and Burton 187) Most people never think of asthma as a life threatening disease, but it can be crucial. As the number of people with asthma increases, the more likely you are to come in contact with someone who has been diagnosed with this disease. Asthma is a severe breathing problem that has many complications that is dealt with daily like shortness of breath, chronic cough, tightness of the chest and shortness of breath, my main focus is childhood asthma, allergic asthma, and medication to treat asthma.
As of 2009, studies conducted by the CDC have shown that asthma impacts approximately one in every twelve people, and the numbers only continue to grow (CDC, 2011). Some of the most common symptoms can range anywhere from coughing (especially at night or during exercise), wheezing and chest tightness, to shortness of breath. Asthma is often a chronic condition and while many times it can present itself as being mild, it can also sometimes lead to death if a person suffers an asthma attack. Asthma can be genetic, but it can also be caused, as well as exacerbated by, environmental factors such as air pollution. Studies have shown that children living in the Bronx are experiencing asthma at levels eight times higher than the national average. In addition, rates of death from asthma are a whopping three times higher than the national average, and hospitalization rates at about five times higher.” (Ruppell, 2000). Asthma is not a disease that targets only one group of people, yet the Bronx still exhibits disproportionately high levels of asthma especially in neighborhoods that are poorer areas of the city. In fact, people from these poor areas are 21 times more likely to be hospitalized due to asthmatic conditions compared to people from more affluent parts of the city (Ruppell,
Asthma affects 1 in every 12 Americans. According to the American Academy of Allergy Asthma & Immunology, Asthma is affects “About 1 in 9 (11%) non-Hispanic blacks of all ages and about 1 in 6 (17%) of non-Hispanic black children had asthma in 2009, the highest rate among racial/ethnic groups.” As a mother of child with asthma, I know how scary it can be to deal with asthma attacks and learning how to treat the symptoms and minimize risk factors.
Avoiding and controlling asthma triggers is important in every phase of the intervention process in order to manage the disease. However, many times because of lack of awareness and education, asthma
Asthma is a chronic condition affecting the respiratory system and has a considerable impact on both individuals and a population. Everybody is susceptible to asthma, some more than others, depending of a variety of factors including, age, sex, geographical location and income. Asthma is particularly prevalent in younger children and the elderly and while it can be fatal, most people have mild cases of asthma that are relatively easy to treat. The condition mainly impacts an individual’s physical ability to contribute to a community.
About 10% of American children have asthma (Thakur et al., 2013). It is vital to understand what determinants cause childhood asthma to understand even with a low percentage, why it is still present. According to Williams et al., asthma is a health outcome which is a major impact on American youth (Williams et al., 2009). This health outcome not only impacts them throughout the years of being a child, but it has the potential of creating more serious health problems in the future. And without knowing what the causes are, it increases the rate asthma among children and prevents treatments from being implemented. It needs to be addressed by using results from prior studies in order to show how much of a problem childhood asthma is but also in finding and understanding the other underlying
According to the National Heart, Lung, and Blood Institute, Asthma is a chronic lung disease that affects the airways, which is comprised of tubes that carry air in and out of the lungs. People who experience difficulties breathing have inflamed airways. The inflammation causes the tubes to swell and become sensitive, especially when inhaling strong substances. As a result, the airways tighten and the muscles around the tubes become swollen and narrower. In addition, cells in the airways might produce more mucus. This sticky and thick mucus makes it even more difficult for air to pass into the lungs.
Discuss the prevalence of asthma in certain patient populations that you might see in primary care. Asthma is chronic airway inflammation disorder that is characterized by persistent episodes of wheezing, breathlessness, chest tightness, and non-productive cough, mainly at night and in the early morning. The inflammation of the airway results from physical, chemical, and pharmacologic stimulus, which causes bronchial hyper-responsiveness, constriction of the airways, edema of airway wall, and chronic airway remodeling (Cash, 2014). Asthma occurs at all ages, with about 50% of all cases developing during childhood and another 30% before age 40. In the United States, it is estimated that 25 million people have asthma and the prevalence continues to increase (McCance, & Huether, 2014). Previously, asthma was considered
Throughout the years knowledge about asthma has grown, as well as treating it effectively. Over 300 million people are said to be victims of this disease with another 100 million being estimated by 2025 globally (Currie and Baker, 2012). In the United Kingdom, asthma is increasingly becoming one of the leading disease affecting individual of different age, ethnicity, race and gender. British Lung Foundation (2011) stated that it is more common at childhood stage and can also occur at a later age. According to Asthma UK (2014) asthma in men is less prevalence than it is in women and children troubled more with asthma than adults. Recent data in the UK shows that in children and occupational asthma in adult is on the rise with an estimate
Asthma is best described as a chronic inflammation the pulmonary lower airways because of hyperresponsiveness of lower airway obstructions that is usually reversible (Fireman, 2003). Asthma is triggered by cold air, exercise, viral upper respiratory infections, cigarette smoking, and respiratory allergens. One in 12 people in the United States has been diagnosed with asthma which is approximately 25 million people which accounts for 8% of the total population (AAAAI, 2016). It is estimated that the average cost for care of asthma in the United States is about $3,300.00 yearly in related medical expenses, missed school, missed worked days and early death (AAAAI, 2016). The purpose of this paper is to describe the long-term treatment
People with a family history of allergies or asthma are more vulnerable to developing asthma. Many people with asthma even have specific allergies. This Is known as allergic asthma.
Asthma is a chronic airway disease that can be difficult to manage, resulting in poor outcomes and high costs (Kuhn et al., 2015). It is characterized by episodes of expiratory airflow obstruction, which occurs in response to multiple stimuli or triggers. Asthma is a lifelong disease, and symptoms include wheezing, breathlessness, chest tightness, and coughing. Attacks can be mild, moderate, severe, or even life threatening and limit a person’s way of life (Centers for Disease Control and Prevention (CDC), 2011). There is no known cure for asthma, but symptoms can be controlled by avoiding the triggers and taking prescribed medicines that prevent or minimize symptoms.