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Ecology Of Asthma

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The Evidence Based Pharmacology of Asthma Management The number of chronic diseases and individuals suffering continues to rise with the ever-growing population. One of these chronic diseases which is very common and affects all age groups as well as ethnic groups is asthma. There are current estimates of the number of individuals suffering from asthma internationally to be 300 million and the chance for the number to reach 400 million by the year 2025 (Alhassan, Hattab, Bajwa, Bihler & Singh, 2016). The condition is responsible for roughly 250,000 international deaths yearly with the prevalence of the disease increasing and despite a decline in deaths within the last decade (Alhassan et al., 2016). Asthma presents more commonly in children …show more content…

Roughly half of all cases of asthma are genetically linked, while the other half of cases are more commonly related to the exposure of environmental factors (Martinez & Vercelli, 2013). The current genetic studies for asthma are limited and require further research to identify the variations between familial tendencies and environment exposures which trigger asthma in individual. However, with cloning practices five genes related to the presence of asthma in individuals have been identified. These genes consist of ADAM33, DPP10, PHF11, SPINK5 and GRPA (World Health Organization (WHO), n.d.). In addition to the identification of underlying genetic links to asthma, the term atopy is most commonly used to explain related genetics and environment susceptibilities for individuals suffering from asthma. Individuals who suffer from asthma are often genetically predisposed to produce IgE in response to environment allergen exposures contributing to the inflammatory response and clinical symptoms of asthma (Arshad, Karmaus, Zhang, & Holloway, 2017). Individuals with family history, an increased level of IgE and positive skin allergies are also predisposed to the risk of asthma (Alhassan et al., 2016). While progress has been made to identify genetic tendencies, further research is required to understand the link …show more content…

The etiology of asthma and pathophysiology has been studied extensively throughout the decades. The condition is one of the most common lung diseases worldwide and is responsible for deaths with a higher prevalence among black Americans and Hispanics (Anise & Hasnain-Wynia, 2016). There is a clear definition of asthma and a consensus of the underlying processes which contributes to the clinical symptoms present in individuals experiencing an acute exacerbation. Asthma is clearly defined as a heterogeneous condition affecting individuals along the life span which is triggered by allergens, non-allergens and viral or bacterial sources (Martinez & Vercelli, 2013). Furthermore, the condition is described as an inflammatory disease of the airway that results in an immune mediated response creating symptoms that may include, bronchoconstriction, wheezing, coughing, increased mucous production and airflow obstruction (Alhassan, 2016 ; Barnes, 2016). The inflammatory response which occurs involves either helper T cells or lymphoid cells depending on the initial trigger and with recurring episodes affect the respiratory system, creating changes structurally to the airway (Barnes, 2016). These changes may consist of thickening of the airway cells, the increased risk of creating mucous plugs within the airway and fibrosis (Barnes,

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