preview

Effects Of Chronic Kidney Disease

Better Essays

Chronic kidney disease (CKD) affects 13% of the population, and it can lead to an increased risk of cardiovascular disease since it is associated with the precipitation of PO4 and Ca. The deposition of PO4 and Ca can consequently lead to the calcification and stiffening of vascular smooth muscle cells of arteries which increases cardiovascular morbidity and mortality. Increased levels of serum magnesium (Mg) are associated with slower development of CVD since Mg helps to upregulate factors that inhibit calcification and downregulate factors that promote calcification. In previous trials, Mg supplementation has been shown to reduce the development and progression of vascular calcification in end-stage renal disease. Studies have also shown …show more content…

36 subjects were admitted to be a part of the trial, and this specific number of participants was chosen based on statistics showing that a sample size of at least 10 people per group would be needed to detect a clinically relevant increase in intracellular Mg. The trial met this requirement since there were three groups, each with 12 participants. The first group, which was randomized from the total sample size, consisted of 12 individuals who consumed a placebo two times a day. The second group, also randomized from the total sample size, consisted of 12 individuals who consumed slow-release Mg hydroxide 360mg, or 15mmol elemental Mg, oral supplements one time a day. The third group, randomized from the total sample size, consisted of 12 individuals who consumed slow-release Mg hydroxide 360 mg, or 15mmol elemental Mg, oral supplements two times a day for a total of 30mmol elemental Mg per day. The trial took place over 8 weeks, and after 0 weeks, 4 weeks, and 8 weeks, sublingual epithelial cells were sampled for intracellular Mg via an energy dispersive x-ray microanalysis of the cells. Other measurements that were taken at 0, 4, and 8 weeks include blood levels of total Mg, PO4, ionized Ca, PTH, 25-hydroxy vitamin D3, fetuin A, albumin, bicarbonate, intact FGF23, eGFR, 24-hour

Get Access