Essay On Renal Failure

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The high prevalence may be expected when there is no homogeneity of RBC antigens between the blood donors and recipients didn’t use leucodepleted red blood cell, didn’t do antigens phenotype (Rh and Kell).

Chronic renal failure

The patients of chronic renal failure who have received blood transfusions are also at risk of alloimmunization. Although, recombinant human erythropoietin (RHuEpo) has revolutionized the treatment of patients with anemia of chronic renal failure but the blood transfusion still final treatment of anemia in chronic renal failure.

We observed of alloimmunization prevalence was 15.4 % detected in 6 out of 39 CRF patients, this finding is higher than the frequency of previous studies have done in Sudan country that
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The high prevalence because most of patients old, heterogeneity of patients with donors and previous pregnancy.

Mother negative blood group

Through literature review all previous studies conformed of mother having negative blood group more prone to antibody formation specific if her fetes was positive blood group.
In our study, we collected from 8 mothers having negative blood group and we found 2 women had immunized (25%). Note that the previous studies that found higher and lower immunization rates. Meena Sidhu et al. 2016 50 found about 2 % (21 % in D-negative and 0.45 % in D-positive), Jophy Varghese et al. 201332 observed that, allosensitization with clinically significant antibodies was found in 9.43 % Rh (D) negative and in 0.08 % Rh (D) positive women. While Jalada Patel et al. 2009(20) reported that bad obstetric history cases had significantly higher incidence of alloimmunization.

Leukemia

Most of leukemia disease associated with anemia, the blood transfusion requeir to treatment anemia additional to compensate of leukocyte cells.
In present study, we collected from 8 patients and found only one immunized patient (12.5%) lower than reported by (Sanz C et al. 2013)34 worked on “Red blood cell alloimmunization in transfused patients with myelodysplastic syndrome or chronic myelomonocytic leukemia”. They found that 42 immunized patients, alloimmunization rate was (15%), formed 81 alloantibodies and

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