The high prevalence may be expected when there is no homogeneity of RBC antigens between the blood donors and recipients didn’t use leucodepleted red blood cell, didn’t do antigens phenotype (Rh and Kell).
Chronic renal failure
The patients of chronic renal failure who have received blood transfusions are also at risk of alloimmunization. Although, recombinant human erythropoietin (RHuEpo) has revolutionized the treatment of patients with anemia of chronic renal failure but the blood transfusion still final treatment of anemia in chronic renal failure.
We observed of alloimmunization prevalence was 15.4 % detected in 6 out of 39 CRF patients, this finding is higher than the frequency of previous studies have done in Sudan country that
…show more content…
The high prevalence because most of patients old, heterogeneity of patients with donors and previous pregnancy.
Mother negative blood group
Through literature review all previous studies conformed of mother having negative blood group more prone to antibody formation specific if her fetes was positive blood group.
In our study, we collected from 8 mothers having negative blood group and we found 2 women had immunized (25%). Note that the previous studies that found higher and lower immunization rates. Meena Sidhu et al. 2016 50 found about 2 % (21 % in D-negative and 0.45 % in D-positive), Jophy Varghese et al. 201332 observed that, allosensitization with clinically significant antibodies was found in 9.43 % Rh (D) negative and in 0.08 % Rh (D) positive women. While Jalada Patel et al. 2009(20) reported that bad obstetric history cases had significantly higher incidence of alloimmunization.
Leukemia
Most of leukemia disease associated with anemia, the blood transfusion requeir to treatment anemia additional to compensate of leukocyte cells.
In present study, we collected from 8 patients and found only one immunized patient (12.5%) lower than reported by (Sanz C et al. 2013)34 worked on “Red blood cell alloimmunization in transfused patients with myelodysplastic syndrome or chronic myelomonocytic leukemia”. They found that 42 immunized patients, alloimmunization rate was (15%), formed 81 alloantibodies and
This is very likely to determine whether Nikoleta’s abnormal red blood cell color and shape is part of a family history. It also notes that both parents have mild hypochromia and macrocytic anemia.
Leukemia broadly describes conditions that affect erythropoiesis in the bone marrow, lymphatic system, and spleen. As with all other cancers, leukemia begins from the mutation of DNA in certain cells. Classifications of leukemias are based on the age of onset and the leukocyte involved (Lewis et al. 2014, 665). The most common leukemia is chronic lymphocytic leukemia (CLL), accounting for approximately 30% of cases in the United States (Copstead and Banasik 2013, 222). The normal function of the bone marrow, spleen, and liver becomes interrupted by the invasion of malignant lymphocytes (B cells); since the B cells are functionally inactive, a patient becomes more susceptible to infections. The sluggish progression of CLL unfortunately leads to late diagnoses and poor prognosis (Lewis et al. 2014, 665). Patients that become symptomatic in later stages will experience fatigue, weight loss, anorexia, and an increased susceptibility to infection, due to abnormal antibody production. Patient specific factors such as age, disease progression, and medication side effects will determine the course of treatment (Copstead and Banasik 2013, 223). The fragile state of patients with CLL requires continuous examination of drug therapy and interventions to prevent further complications.
Some reasons someone would need a blood transfusion are through chemotherapy, low blood counts, kidney disease, blood cancer patients, and excesses bleeding.
People with severe anemia may require a blood transfusion. A person with an immune disorder may need to receive injections of antibodies (immune globulin).
Leukemia is a type of cancer that affects the production of white blood cells. The cells that are produced are abnormal and cannot complete their function effectively. This research paper will discuss leukemia, and assess how it affects the anatomy and physiology of the affected patient. The paper will compare the anatomy and physiology of a normal human being to that of a patient with leukemia. The paper will also consider several parameters that are of importance when talking about leukemia, such as statistics, signs, and symptoms of the condition, causes, prevention, diagnosis, treatment, and prognosis. Blood cells are manufactured in the bone marrow and lymphatic system. The bone marrow is the soft and spongy part tissue of the bones. In patients with leukemia, the white blood cells are produced abnormally. There are three major types of white blood cells: lymphocytes, monocytes, and granulocytes. There are several types of leukemia: chronic myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphatic leukemia. These types of cancers differ in the manner in which the cancer originates and progresses.
Once placing anti-b serum on the blood sample, we again mixed with a clean toothpick and the blood had no reaction. These results determine that Mr. Thomas is blood type A because the anti-a serum caused the A alleles to clot. Next, we tested on Mrs. Thomas. After placing anti-a serum on Mrs. Thomas’s blood sample, we mixed with a clean toothpick and saw that there was no reaction occuring in the blood. Once placing anti-b serum on the blood sample, we mixed with a clean toothpick and the blood also had no reaction. These results determine that Mrs. Thomas is blood type O because both the anti-a serum and anti-b serum caused no reaction within the blood. After determining the blood type of Mr. and Mrs. Thomas, we determined the blood type of the children. After placing anti-a serum on Child One’s blood sample, we mixed with a clean toothpick and saw that there was aggulating or clumping occuring in the blood. Once placing anti-b serum on the blood sample, we mixed with a clean toothpick and the blood had no reaction. These results determine that Child One has blood type A because the anti-a serum caused the A alleles to clot. Once placing anti-a serum on Child Two’s blood sample, we mixed with a clean toothpick and saw that
The purpose of this lab is to correctly determine the blood type of four unknown synthetic blood samples through the use of three antibody serums; anti-A, anti-B and anti-Rh. By successfully determining the blood type of an individual, information such as the individual 's blood antigens and antibodies will be known and can help determine which blood types that individual can accept or donate.
Aplastic anemia (bone marrow failure) is anemia caused by the inability of the bone marrow to produce blood cells. Aplastic anemias are much rarer than dietary deficiency or genetic defect anemias, and progess rapidly.
There are several ways to treat Myelodysplastic Syndromes. The plan of action of one’s treatment depends on the severity of the syndrome and age. Types of standard treatment are supportive care, drug therapy, and chemotherapy with stem cell transplant. Supportive care is used to reduce problems or side effects associated with the syndrome or its treatment. One supportive care option is blood transfusion. Transfusions can be specific to the type of cytopenias. For example, if a patient is experiencing anemia, a red blood cell transfusion is given. Platelet transfusions are given when a patient is bleeding easily, platelet count is low, or when the patient is having a procedure that may cause bleeding. Patients can also receive transfusions to
In-order-to test this hypothesis the Investigators pricked their fingers in order to bleed. Once the investigators began to bleed they squeezed drops of blood out of the small wound on to wells on the blood test card. The wells were labeled “anti-A,” “anti-B,” and “anti-D.” After they bleed into the wells, the investigators dropped one drop of anti-A serum in the well labeled “anti-A,” one drop of anti-B serum in the well labeled “anti-B,” and one drop of anti-D serum in the well labeled “anti-D.” In order to test for the Rh factor, the investigators mixed, with a serial toothpick, the anti-D and the Blood. Our hypothesis was correct with forty-five percent of the class having type A positive or O positive
This disease is very preventable, so catching it early is good for mother and baby. If left untreated, it might kill the fetus.
Chemotherapy regimens vary based on the clinical status and medical history of patients. The objective of chemotherapy is to stabilize the normal blood cell counts and the normal hematopoiesis to be less than 5% blast cells in the bone marrow (Overview of Leukemia - Hematology and Oncology - Merck Manuals Professional Edition, “n.d.”). Moreover, chemotherapy targets to limit or elicit cloning of leukemic cells. Patients with bleeding, anemia, and neutropenia are provided with transfusion of platelets, RBCs, and granulocytes. Immunosuppressive and neutropenic patients are administered antimicrobials to prevent serious progression of infection. Under chemotherapy, patients can experience hyperuricemia, hyperphosphatemia, hypocalcemia, and hyperkalemia due to leukemic cell ruptures hence monitoring and providing hydration and electrolyte, and level of urine alkalinization is required. Furthermore, revival of leukemic cells in the bone marrow, the CNS, the testes, or other sites is threatening. Chemotherapy may not be most effective treatment or permanent cure. Therefore, stem cell transplantation offers effective and long-term cure if patient can find matching stem cells to be transferred. “Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers (leukemias, lymphomas, myeloma) and other hematologic disorders (eg, primary immunodeficiency, aplastic anemia, myelodysplasia).” (Hematopoietic Stem Cell Transplantation Leukemia - Hematology and Oncology - - Merck Manuals Professional Edition,
RBCs encounter different antigens on the surface of their cell membrane. If a donor RBCs antigens do not match with the RBCs antigen of the recipient that means donor and recipient are incompatible for transfusion.
Another important consideration is the rarity of blood type. People with type AB are, indeed, unique individuals sharing their blood type with only 3% of the population. Because this type shows A and B genes, it inherits type A’s low stomach acid and type B’s adaptation to meats, where meats get stored as fat due to low stomach acid. Type AB also shows a correlation with anemia, heart disease and bronchial infections. It is also common for this blood type to show inhibited insulin production which may result in hypoglycemia and a less efficient metabolism of foods. Another rare blood type is type O negative. It is a special type that is most in demand by hospitals since it can treat people with any blood type due to its lack of antigens. However,
The purpose of this lab is to determine the blood type of two samples. The objectives of the blood typing lab were to learn about antigens and the consequences of incompatibility, blood typing, and to illustrate antigen-antibody complexes and agglutination.