Evaluation And Effectiveness Of Packaged Red Blood Cells Essay

The market of human blood transfusions is broken down into different uses: Elective Surgery, Emergency Surgery and Trauma. However, Hemopure seems to be suitable only for trauma cases due to its characteristics and, again, high price. To understand the reason, it is important to notice that, actually, only 10% of the 500,000 trauma victims receives RBCs “in the field” or at the site of accident, and the remaining 95% of these people does not receive transfusions until they arrive at the hospital. This delay was often cited as a major factor to the 20,000 trauma deaths. Therefore, since the expected market share for Biopure is 25% and assuming that the total blood transfusions remain stable, the potential market size for Hemopure is approximately $350,000,000. This size is based on an average price of $700 multiplied by 2,000,000 units (around 4 blood units are needed for each Trauma case).

The Indicated Review had 80 studies involving 11,337 students (Weissberg, Taylor, Schellinger, Payton, Pachan, Dymicki and Durlak,

Analyze and critically appraise evidence-based literature to support the solution to the identified problem. A minimum of (5) articles must be identified. This may include guidelines from the National Guideline Clearinghouse, Joanna Briggs Institute, or a review from the Cochrane Database of Systematic Review.

The current review was managed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines (Moher et al., 2009) and established guidelines for narrative synthesis by Popay et al. (2006).

Recently, the American Red Cross issued an “Urgent: Blood Appeal” to inform the community of

The study was a systematic review of scientific papers selected by a search of the SciELO, Cochrane, MEDLINE, and LILACS-BIREME databases. Among the 2169 articles found, 12 studies proved relevant to the issue and presented an evidence strength rating of B. No publications rated evidence strength A. Seven of the studies analyzed were prospective cohorts and 5 were cross-sectional studies.

Furthermore, prompt infusion of antimicrobial agents ought to be priority and this may require extra vascular access ports (Dellinger, et al., 2008). Early goal-directed resuscitation has confirmed to improved survival for emergency department patients presenting with septic shock in a randomized, controlled, single-center study. Resuscitation lessen 28-day death rate (Dellinger, et al., 2008). In a reviewed conducted by Dellinger, et al., (2012) advocated administering one litre of crystalloid or 300-500ml of colloid more than 30 minutes, to accomplish a central venous pressure (CVP) of 8 mm Hg to 12 mm Hg. Volumes ought to be increased if there are huge indications of hypoperfusion (Dellinger, 2014).

For the literature review an electronic search was undertaken of articles published in English using the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed and Cochrane databases from 2009 to 2013 were searched for medical subject heading terms, both individual terms and combination of the following

The lesson and case studies presented for evaluation was a great learning exercise. A better understanding of how to interpret data was gained. Also, weighing the clinical significance versus the statistical significance to show relevance is invaluable. All research is not quality research and one must be equipped to recognize bias, threats to validity and proper population representation. Moreover, critiquing the credibility of a study is essential to the health care advances.

o Review of related literature: In what ways does the literature review support the need for this study?

Future Researchers: this study will serve as a guide and reference and baseline information to further develop studies. The study can also open in development of the study.

Cullen and Gendreau compare and contrast the many studies on this subject, the meta-analyses conclusions, their strengths, weaknesses, inconsistencies, and the trends that follow the studies

Additionally, there will be a table to summarise the key characteristics of the studies relevant to the clinical question. Furthermore, there will be a critical review of the findings and on how this review could be incorporated into practice with consideration to the facilitators and barriers to implementing evidence, and strategies to support a validated framework in my workplace. Finally, this paper will conclude with a brief summary of the main points

Several databases were used for this review. Sources primarily came from EBSCO, which included Academic Search Complete, Education Full Text, OmniFile Full Text Mega, General Science Full Text, EBSCO Professional Development Collection, and Social Sciences Full-Text databases. In addition, the EBSCO eBook Collection and the EBSCO ebrary collection for full-text books were utilized. Other databases used for this review include Google Scholar and ERIC. The search was narrowed by limiting sources to academic journals and books. Where possible, only peer-reviewed sources were used. Some keyword descriptors did not produce results within the peer-review parameters.

Five published studies met the selection criteria. Two authors using a standard concept to form independent data. Odds ratios with 4